Magnetic fields generated by an induction heating (IH) CookTop do not cause Genotoxicity in vitro
Magnetic fields generated by an induction heating (IH) CookTop do not cause Genotoxicity in vitro
复制标题
DOI：
10.1002/bem.20334
复制
发表时间：
2007-10-01
影响因子：
1.9
通讯作者：
Sakurai, Tomonori
中科院分区：
文献类型：
--
作者：
Miyakoshi, Junji;Horiuchi, Erni;Sakurai, Tomonori
在家庭中使用感应加热器（IH）灶台已经变得普遍，特别是在日本，但人们担心与这些烹饪器具相关的中频电磁场的安全性。由于尚未在培养细胞中检测中频磁场的细胞遗传毒性，我们使用带有内置CO2培养箱的暴露单元，在23 kHz的磁通量密度为532 20 mu T时检测了这些磁场的影响。在532 μ T的中频磁场下暴露2 h不影响CHO-K1细胞的生长，在细菌突变实验中没有引起诱变作用。在彗星试验中，暴露于中频磁场2小时既没有引起单双DNA链断裂，也没有引起HPRT位点突变频率的显著变化。在这项研究中使用的磁场比国际非电离辐射防护委员会（ICNIRP）指南中建议的安全水平高出80倍以上。根据这些结果，我们认为暴露于中频磁场2小时不会引起细菌和中国仓鼠细胞的细胞遗传毒性。然而，对其他细胞功能的影响可能性仍然存在，需要进一步研究中频磁场对细胞的影响。
The use of induction heater (IH) cook tops in homes has become widespread, especially in Japan, but there are concerns about the safety of intermediate frequency (IF) electromagnetic fields associated with these cooking appliances. Since the cellular genotoxicity of IF magnetic fields has not been examined in cultured cells, we examined the effects of these fields at a magnetic flux density of 532 20 mu T at 23 kHz, using an exposure unit with a built-in CO2 incubator. Exposure to the IF magnetic field at 532 mu T for 2 h did not affect the growth of CHO-K1 cells and caused no mutagenic effects in bacterial mutation assays. Exposure to the IF magnetic field for 2 h induced neither single nor double DNA strand breaks in comet assays, and caused no significant change in the mutation frequency at the HPRT locus compared to sham exposure. The magnetic field used in this study is more than 80 times higher than the level recommended as safe in the International Commission on Non-ionizing Radiation Protection (ICNIRP) guidelines. From these results, we suggest that exposure to an IF magnetic field for 2 h does not cause cellular genotoxicity in bacteria and in Chinese hamster cells. However, the possibility of effects on other cellular functions remains, and further studies on the cellular effects of IF magnetic fields are required.