ABDOMINAL ADIPOSE-TISSUE DISTRIBUTION, OBESITY, AND RISK OF CARDIOVASCULAR-DISEASE AND DEATH - 13 YEAR FOLLOW UP OF PARTICIPANTS IN THE STUDY OF MEN BORN IN 1913
ABDOMINAL ADIPOSE-TISSUE DISTRIBUTION, OBESITY, AND RISK OF CARDIOVASCULAR-DISEASE AND DEATH - 13 YEAR FOLLOW UP OF PARTICIPANTS IN THE STUDY OF MEN BORN IN 1913
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DOI：
10.1136/bmj.288.6428.1401
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发表时间：
1984-01-01
影响因子：
105.7
通讯作者：
TIBBLIN, G
中科院分区：
文献类型：
--
作者：
LARSSON, B;SVARDSUDD, K;TIBBLIN, G
在一项缺血性心脏病危险因素的前瞻性研究中，792名54岁的男性，按出生年份（1913年）和居住地选择在哥德堡[瑞典]同意参加询问和一组人体测量和其他测量于1967年。13年后，这些基线研究结果与随后发生中风、缺血性心脏病或各种原因死亡的男性人数进行了比较。无论是五分位数还是十分位数的初始肥胖指数（体重指数，3个皮褶厚度测量值的总和，腰围或臀围）显示与任何研究的3个终点显着相关。腰臀比与中风（P = 0.002）和缺血性心脏病（P = 0.04）的发生率之间存在统计学显著相关性。当考虑体重指数或3个皮褶厚度之和的混杂效应时，腰围/臀围比与所有3个终点显著相关。然而，当考虑到吸烟、收缩压和血清胆固醇浓度时，该比值不是这些终点的独立长期预测因子。在中年男性中，脂肪沉积的分布可能比肥胖程度更能预测心血管疾病和死亡。
In a prospective study of risk factors for ischemic heart disease, 792 54 yr old men selected by year of birth (1913) and residence in Gothenburg [Sweden] agreed to attend for questioning and a battery of anthropometric and other measurements in 1967. Thirteen years later these baseline findings were reviewed in relation to the numbers of men who had subsequently suffered a stroke, ischemic heart disease, or death from all causes. Neither quintiles nor deciles of initial indices of obesity (body mass index, sum of 3 skinfold thickness measurements, waist or hip circumference) showed a significant correlation with any of the 3 end points studied. Statistically significant associations were found between the waist to hip circumference ratio and the occurrence of stroke (P = 0.002) and ischemic heart disease (P = 0.04). When the confounding effect of body mass index or the sum of 3 skinfold thicknesses was accounted for, the waist to hip circumference ratio was significantly associated with all 3 end points. This ratio, however, was not an independent long-term predictor of these end points when smoking, systolic blood pressure and serum cholesterol concentration were taken into account. In middle aged men the distribution of fat deposits may be a better predictor of cardiovascular disease and death than the degree of adiposity.