Serum retinol-binding protein 4 levels and risk of gestational diabetes mellitus: a nested case-control study in Chinese women and an updated meta-analysis.
Serum retinol-binding protein 4 levels and risk of gestational diabetes mellitus: a nested case-control study in Chinese women and an updated meta-analysis.
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血清视黄醇结合蛋白 4 水平与妊娠糖尿病风险：中国女性的巢式病例对照研究和更新的荟萃分析。
DOI：
10.1002/dmrr.3496
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Pan An
中科院分区：
文献类型：
--
作者：
Wu Ping;Wang Yi;Ye Yi;Yang Xue;Lu Qi;Liu Yan;Zeng Huayan;Song Xingyue;Yan Shijiao;Wen Ying;Qi Xiaorong;Yang Chun-Xia;Liu Gang;Lv Chuanzhu;Pan Xiong-Fei;Pan An
目的：前瞻性评估妊娠早期循环视黄醇结合蛋白4 （RBP4）水平与妊娠期糖尿病（GDM）发生风险的关系。方法采用巢式病例对照研究，选取同济-双流出生队列的332例GDM妇女和664例匹配对照。根据国际糖尿病和妊娠研究小组的标准，妊娠24-28周诊断为GDM。采用ELISA法检测妊娠早期（妊娠6 ~ 15周）血清RBP4水平。使用多变量条件逻辑回归模型分析相关性，并生成优势比（OR）和95%置信区间（CI）。EMBASE和PubMed检索了截至2020年11月30日的研究，以确定调查妊娠早期血液RBP4水平与GDM发生之间关系的研究。结果在校正潜在危险因素的多变量模型中，比较血清RBP4水平的极端四分位数的OR为2.26 (95% CI: 1.34, 3.81；趋势p <0.001)， RBP4每增加一个标准差（SD）， GDM风险增加1.39倍（95% CI: 1.15, 1.69）。结果在一项meta分析中得到证实，该meta分析包括另外四项研究，RBP4每增加1‐SD，总体OR为1.47 （95% CI: 1.18, 1.83）。结论妊娠早期血清RBP4水平与妊娠期GDM风险呈正相关，不受代谢危险因素的影响。我们的发现可能为GDM的病因机制提供新的见解。
AimsWe prospectively evaluated the association of circulating retinol‐binding protein 4 (RBP4) levels in early pregnancy and risk of incident gestational diabetes mellitus (GDM) in pregnant women.MethodsA nested case‐control study was conducted among 332 women who developed GDM and 664 matched controls based on the Tongji‐Shuangliu Birth Cohort. GDM was diagnosed during 24–28 weeks of gestation according to the International Association of Diabetes and Pregnancy Study Group criteria. Serum RBP4 levels in early pregnancy (6–15 weeks of gestation) were determined by ELISA assay. Multivariable conditional logistic regression models were used to analyse the association and generated the odds ratio (OR) and 95% confidence interval (CI). EMBASE and PubMed were searched up to 30 November 2020 to identify studies investigating the association between blood RBP4 levels in early pregnancy and incident GDM.ResultsIn the multivariable model with adjustment of potential risk factors, the OR comparing the extreme quartiles of serum RBP4 levels was 2.26 (95% CI: 1.34, 3.81;pfor trend <0.001), and each standard deviation (SD) increment of RBP4 was associated with 1.39‐fold (95% CI: 1.15, 1.69) higher risk of GDM. The results were confirmed in a meta‐analysis that included additional four studies with an overall OR of 1.47 (95% CI: 1.18, 1.83) per 1‐SD increment of RBP4.ConclusionsSerum RBP4 levels in early pregnancy, independent of metabolic risk factors, are positively associated with the risk of GDM in pregnant women. Our findings may provide new insights into the mechanisms underlying the aetiology of GDM.