Mucoepidermoid carcinoma arising in Warthin's tumor of the parotid gland: Clinicopathological characteristics and immunophenotypes.
Mucoepidermoid carcinoma arising in Warthin's tumor of the parotid gland: Clinicopathological characteristics and immunophenotypes.
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DOI：
10.1038/srep30149
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发表时间：
2016-07-15
影响因子：
4.6
通讯作者：
Dong X
中科院分区：
文献类型：
--
作者：
Yu C;Song Z;Xiao Z;Lin Q;Dong X
粘液表皮样癌是一种非常罕见的肿瘤，起源于腮腺沃辛瘤的上皮成分。在解放军总医院和首都医科大学北京世纪坛医院手术切除的309例WTs中，5例（1.6%）符合WTs转化为MEC的标准。为了避免误诊，本文对MEC的临床病理特征进行了分析。5例均为腮腺区无痛性肿块，男3例，女2例。MEC位于WT的内部或边缘，WT和MEC之间有明显的过渡带。WT基底细胞和MEC表皮样细胞CK 5/6、CK 34 βE12和P63强阳性，CK 7、CK 20和CEA阴性。MEC粘液细胞CK 7、CEA、PAS阳性，CK 5/6、CK 34 βE12、CK 20、P63阴性。MECs患者术后随访25-69个月，无复发或转移的证据。总的来说，WT引起的MEC非常罕见。病理诊断主要依据组织学形态，尤其是WT与MEC之间的过渡带。
Mucoepidermoid carcinoma (MEC), an extremely rare tumor, arises from the epithelial component of preexisting parotid Warthin tumors (WT). Among the 309 cases of surgically resected WTs in Chinese PLA General Hospital and Beijing Shijitan Hospital of Capital Medical University, 5 cases (1.6%) fulfilled the criteria for MECs transformed from WTs. Clinicopathological characteristics of MECs was demonstrated in order to avoid misdiagnosis of this rare type of tumor. All the 5 patients, 3 males and 2 females, presented painless masses in the parotid gland. MECs were located inside or at the edge of WTs, with an obvious transitional zone between WT and MEC. Basal cells of WTs and epidermoid cells of MECs were strongly positive for cytokeratin CK5/6, CK34βE12, and P63; whereas negative for CK7, CK20, and CEA. Mucous cells of MECs were positive for CK7, CEA, as well as periodic acid-Schiff (PAS), whereas negative for CK5/6, CK34βE12, CK20, and P63. MECs patients were followed up for 25–69 months after surgery, presenting no evidence of recurrence or metastasis. Collectively, MECs arising from WT is very rare. The pathological diagnosis was based on histological morphology, especially the transitional zone between WT and MEC.