INTRAPLEURAL INSTILLATION OF STREPTOKINASE EFFECTS ON SYSTEMIC FIBRINOLYSIS
INTRAPLEURAL INSTILLATION OF STREPTOKINASE EFFECTS ON SYSTEMIC FIBRINOLYSIS
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DOI：
10.1055/s-2007-1023459
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发表时间：
1981-01-01
影响因子：
1.5
通讯作者：
WILLIAMOLSSON, G
中科院分区：
文献类型：
--
作者：
BERGLIN, EWO;EKROTH, R;WILLIAMOLSSON, G
连续 10 例年龄 25 至 75 岁的术后脓胸或血胸患者，常规引流治疗效果不佳，接受链激酶（Kabikinase®，250.000 IE）胸腔内滴注 4 小时 [1]）。研究了对全身纤维蛋白溶解的影响。在滴注前、滴注后和24小时后采集静脉血样本，用于测定纤维蛋白板上的纤溶活性、纤溶酶原、α2-抗纤溶酶、α2-巨球蛋白纤维蛋白原、纤维蛋白（原）降解产物（FDP）和凝血酶时间。通过学生配对 t 检验将滴注前的值与滴注后 4 小时和 24 小时的值进行比较。纤溶活性、α2-巨球蛋白和凝血酶时间没有差异。纤溶酶原、α2-抗纤溶酶和纤维蛋白原略有增加，可能是由于急性期反应。纤维蛋白降解产物显示出具有边界显着性的增加。这些变化与全身纤维蛋白溶解不一致，因此得出的结论是，在创伤后早期或术后时期可以安全地进行链激酶胸腔内滴注。
Ten consecutive patients aged 25 to 75 with postoperative empyema or hemothorax conventionally treated with drainage without sufficient effect were given intrapleural instillations of streptokinase (Kabikinase®, 250.000 IE) for 4 hours [1]). The effects on systemic fibrinolysis were studied. Venous blood samples for determination of fibrinolytic activity on fibrin plates, plasminogen, α 2-antiplasmin, α 2-macroglobulin fibrinogen, fibrin (ogen) degradation products (FDP) and thrombin time were taken before instillation, after instillation and then after 24 hours. Preinstillation values were compared to the values 4 and 24 hours after instillation with Student's paired t-test. There were no differences in fibrinolytic activity, α 2-macroglobulin and thrombin time. There was a slight increase in plasminogen, α 2-antiplasmin and fibrinogen, probably due to an acute phase reaction. Fibrin degradation products showed an increase with border line significance. These changes are not consistent with generalized fibrinolysis, and it is concluded that intrapleural instillations of streptokinase can be given safely in the early posttraumatic or postoperative period.