Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects
Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects
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DOI：
10.1038/hr.2011.76
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发表时间：
2011-09-01
影响因子：
5.4
通讯作者：
Abe, Youichi
中科院分区：
文献类型：
--
作者：
Fukui, Toshiki;Yamauchi, Kazuhiro;Abe, Youichi
近年来，氧化应激被认为是生活方式相关疾病发病和发展的重要因素。在这项研究中，我们研究了活性氧代谢产物（d-ROM）的衍生物之间的关联，作为活性氧（ROS）的产品的指标，和生物抗氧化潜力（BAP），作为抗氧化潜力的指标。我们还调查了d-ROM或BAP与生活方式相关疾病或代谢综合征相关因素的风险因素之间的关联，以评估其在预防医学中的有用性。共有442名受试者在我们的机构进行健康检查。除了标准的体检项目，我们分析了d-ROM，BAP，臂踝脉搏波速度，高敏C反应蛋白水平和内脏脂肪面积（VFA）可视化的计算机断层扫描。女性的平均d-ROM值显著高于男性。d-ROM与VFA水平呈正相关。相关分析显示，d-ROM与肌酐水平呈负相关。作为影响d-ROM的因素，选择VFA的水平，表明用d-ROM测量氧化应激的意义。此外，d-ROM和BAP值之间呈正相关。需要进一步的研究来解决是否增加ROS的产生或抗氧化剂的潜力，可以补偿这种增加的ROS是更重要的体内。高血压研究（2011）34，1041-1045; doi：10.1038/hr.2011.76;在线发表2011年6月16日
In recent years, oxidative stress has been postulated to be an important factor in the pathogenesis and development of lifestyle-related diseases. In this study, we investigated the association between the derivatives of reactive oxygen metabolites (d-ROMs), as an index of products of reactive oxygen species (ROS), and biological antioxidant potential (BAP), as an index of antioxidant potential. We also investigated the associations between d-ROMs or BAP and the risk factors for lifestyle-related diseases or metabolic syndrome-associated factors to evaluate their usefulness in preventive medicine. There were 442 subjects who underwent health checkup examination in our facilities. In addition to standard medical checkup items, we analyzed d-ROMs, BAP, brachial-ankle pulse wave velocity, high-sensitivity C-reactive protein level and visceral fat area (VFA) visualized on a computed tomography scan. The mean d-ROM value in females was significantly higher than that in males. There was a positive correlation between the d-ROM and VFA levels. On correlation analysis, there was a negative correlation between the d-ROM and creatinine levels. As factors that influence d-ROMs, the level of VFA was selected, suggesting the significance of oxidative stress measurement with d-ROMs. In addition, there was a positive correlation between d-ROMs and BAP values. Further research is required to resolve whether increased production of ROS or the antioxidant potential that can compensate for such an increase of ROS is more important in vivo. Hypertension Research (2011) 34, 1041-1045; doi: 10.1038/hr.2011.76; published online 16 June 2011