Oral mucosa is a useful substrate for detecting autoantibodies of mucous membrane pemphigoid.
Oral mucosa is a useful substrate for detecting autoantibodies of mucous membrane pemphigoid.
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口腔粘膜是检测粘膜类天疱疮自身抗体的有用基质。
DOI：
10.1111/bjd.15925
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Shimizu H.
中科院分区：
文献类型：
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作者：
Kamaguchi M;Iwata H;Ujiie H;Izumi K;Natsuga K;Nishie W;Asaka T;Kitagawa Y;Shimizu H.
亲爱的编辑，粘膜类天疱疮（MMP）是一种罕见的自身免疫性起泡疾病，靶向胶原蛋白XVII（COL17）的C末端。1大疱性类天疱疮（BP）是最常见的自身免疫性水疱性疾病，靶向COL17的非胶原（NC）16A结构域。2虽然MMP和BP的主要受累器官不同，但组织学和免疫学表现相似，但抗原和表位不同，MMP自身抗体的检出率低于BP。3间接免疫荧光（IIF）是最方便的，使用正常人皮肤（NHS）进行，即使MMP主要涉及粘膜。4因此，我们推测正常人口腔粘膜（NHOM）可能会增加MMP自身抗体检测的敏感性。
DEAR EDITOR, Mucous membrane pemphigoid (MMP) is a rare autoimmune blistering disease targeting the C-terminus of collagen XVII (COL17). 1 Bullous pemphigoid (BP) is the most common autoimmune blistering disease targeting the noncollagenous (NC) 16A domain of COL17. 2 Although the predominantly involved organs differ between MMP and BP, the histological and immunological findings are similar, except for the antigens and epitopes.Autoantibodies of MMP are detected less frequently in MMP than in BP because of the titre level. 3 Indirect immunofluorescence (IIF) is the most convenient, and performed using normal human skin (NHS) even though MMP mainly involves the mucosa. 4 Therefore, we hypothesize that normal human oral mucosa (NHOM) may increase the sensitivity for detecting autoantibodies of MMP.