Serum uric acid and leptin levels in metabolic syndrome: a quandary over the role of uric acid
Serum uric acid and leptin levels in metabolic syndrome: a quandary over the role of uric acid
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DOI：
10.1016/j.metabol.2007.01.006
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发表时间：
2007-06-01
影响因子：
9.8
通讯作者：
Weng, Hsiao-Fen
中科院分区：
文献类型：
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作者：
Lin, Jen-Der;Chiou, Wen-Ko;Weng, Hsiao-Fen
本研究旨在探讨尿酸（UA）对代谢综合征相关危险因素的影响。此外，本研究还探讨了代谢综合征患者UA与胰岛素抵抗及血清瘦素水平的关系。研究对象为林口长庚医学中心健康管理科共470名研究对象（252名女性和218名男性）。代谢综合征的定义采用改良的成人治疗组III（ATP 111）定义。胰岛素抵抗（HOMA-1 R）的稳态模型评估公式如下：空腹血清胰岛素（μ U/mL）×空腹血糖（mmol/L）/22.5。45例受试者（9.6%）诊断为糖尿病; 82例受试者（17.4%）患有高血压。144例受试者（30.6%）被诊断为高尿酸血症。在这些受试者中，115例（63例女性和52例男性）（24.5%）被诊断为代谢综合征。高尿酸血症患者的体重指数、腰臀比和甘油三酯（Tg）水平增加。受试者的高密度脂蛋白水平也较低，高血压程度也较高。激素检测显示高尿酸血症组瘦素、免疫反应性胰岛素（IRI）和HOMA-IR升高。尿酸似乎与Tg、血压（收缩压和舒张压）、肥胖、免疫反应性胰岛素和HOMA-IR有更好的相关性。尿酸与瘦素或血糖水平无关。以3.8为界值，代谢综合征和Tg/高密度脂蛋白比值在HOMA-IR中显示出统计学显著性差异。除此之外，瘦素值无差异。结论：除血糖外，血尿酸与代谢综合征的危险因素有显著相关性。腰臀比和HOMA-IR在有和无代谢综合征的受试者中有统计学差异。(C)2007年爱思唯尔公司All rights reserved.
This study investigates the impact of uric acid (UA) on the risk factors associated with metabolic syndrome. In addition, this study explores the relationship between UA and insulin resistance and serum leptin levels in metabolic syndrome. A total of 470 subjects (252 women and 218 men) were recruited from the Department of Health Management at Chang Gung Medical Center (Linkou, Taiwan). Metabolic syndrome was defined using a modified Adult Treatment Panel III (ATP 111) definition. The formula for the homeostasis model assessment of insulin resistance (HOMA-1R) is as follows: fasting serum insulin (mu U/mL) x fasting plasma glucose (mmol/L)/22.5. Diabetes mellitus was diagnosed in 45 subjects (9.6%); 82 subjects (17.4%) had hypertension. Hyperuricemia was diagnosed in 144 subjects (30.6%). Of these subjects, 115 (63 females and 52 males) (24.5%) were diagnosed as having metabolic syndrome. Patients with hyperuricemia had increased body mass index, waist-to-hip ratio, and triglyceride (Tg) level. The subjects also had lower high-density lipoprotein and greater hypertension. Hormone assays showed an elevation of leptin, immunoreactive insulin (IRI), and HOMA-IR in the hyperuricemia group. Uric acid appeared to be better correlated with Tg, blood pressure (both systolic and diastolic), obesity, immunoreactive insulin, and HOMA-IR. Uric acid did not correlate with leptin or blood glucose levels. Metabolic syndrome and Tg/high-density lipoprotein ratio showed a statistically significant difference in HOMA-IR using 3.8 as a cutoff value. Otherwise, there was no difference in leptin value. In conclusion, serum UA is significantly related to risk factors of metabolic syndrome except for blood glucose. Waist-to-hip ratio and HOMA-IR were statistically different in subjects with and without metabolic syndrome. (C) 2007 Elsevier Inc. All rights reserved.