Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging
Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging
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DOI：
10.1001/archopht.123.12.1715
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发表时间：
2005-12-01
影响因子：
--
通讯作者：
de Boer, JF
中科院分区：
文献类型：
--
作者：
Chen, TC;Cense, B;de Boer, JF
目的：介绍一种新的眼科光学相干断层扫描技术，允许前所未有的同时超高速和超高resolution.Methods：使用超发光二极管源，临床上可行的超高速，超高分辨率的光谱域光学相干断层扫描系统的开发。下午6点的决议。使用一个不同的源在一个稍慢的配置，单一的图像组成的500个Ascan在34毫秒内获得，允许在29帧每秒的轴向分辨率为3.5 μ m，这是3倍优于市售的光学相干断层扫描仪器成像。两种情况下射入眼睛的能量均为600 μ W，低于Stratus OCT 3的能量，并且对于在同一视网膜位置进行长达8小时的束内观察是安全的。结果：视网膜、视神经乳头和视网膜血流的体内图像以每次A扫描34.1微秒（ms）的超高速获得，其比商业上可获得的光学相干断层成像仪器快73倍。在34.1 ms内采集由1000次A扫描组成的单个图像（B扫描），允许以每秒29帧的视频速率成像，轴向分辨率为6 pm。使用一个不同的源在一个稍慢的配置，单一的图像组成的500个Ascan在34毫秒内获得，允许在29帧每秒的轴向分辨率为3.5 μ m，这是3倍优于市售的光学相干断层扫描仪器成像。在这两种情况下，600 μ W的能量直接进入眼睛，是小于的Stratus OCT 3，是安全的intrabeam查看长达8小时，在相同的retinal location.Conclusion：光谱域光学相干断层扫描技术，使前所未有的同时超高速和高分辨率的眼科成像。
Objective: To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution.Methods: Using a superluminescent diode source, a clinically viable ultra-high speed, ultra-high resolution spectral domain optical coherence tomography system was developed. resolution of 6 pm. Using a different source in a slightly slower configuration, single images consisting of 500 Ascans were acquired in 34 ms, allowing imaging at 29 frames per second at an axial resolution of 3.5 mu m, which is 3 times better than commercially available optical coherence tomography instruments. The amount of energy directed into the eye in both cases, 600 mu W, is less than that of the Stratus OCT3 and is safe for intrabeam viewing for up to 8 hours at the same retinal location.Results: In vivo images of the retina, the optic nerve head, and retinal blood flow were obtained at an ultra-high speed of 34.1 microseconds (ms) per A-scan, which is 73 times faster than commercially available optical coherence tomography instruments. Single images (B-scans) consisting of 1000 A-scans were acquired in 34.1 ms, allowing video rate imaging at 29 frames per second with an axial resolution of 6 pm. Using a different source in a slightly slower configuration, single images consisting of 500 Ascans were acquired in 34 ms, allowing imaging at 29 frames per second at an axial resolution of 3.5 mu m, which is 3 times better than commercially available optical coherence tomography instruments. The amount of energy directed into the eye in both cases, 600 mu W, is less than that of the Stratus OCT3 and is safe for intrabeam viewing for up to 8 hours at the same retinal location.Conclusion: Spectral domain optical coherence tomography technology enables ophthalmic imaging with unprecedented simultaneous ultra-high speed and ultrahigh resolution.