A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes.
A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes.
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DOI：
10.14348/molcells.2015.0126
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发表时间：
2015-07
影响因子：
3.8
通讯作者：
Kim EK
中科院分区：
文献类型：
--
作者：
Park S;Sadanala KC;Kim EK
肥胖和糖尿病是由遗传和环境因素之间复杂的相互作用引起的。众所周知，肥胖在胰岛素抵抗和糖尿病的发展中起重要作用。然而，肥胖和糖尿病之间联系的确切机制仍不完全清楚。代谢组学是一种旨在检测和定量小代谢物的分析方法。最近，人们对代谢组学应用于疾病生物标志物的鉴定越来越感兴趣，鉴定了许多众所周知的生物标志物。代谢组学是一种有效的方法来解开代谢，肥胖和糖尿病进展之间的复杂关系，同时，有潜力作为风险评估和疾病监测的临床工具。此外，代谢组学的应用已经揭示了与肥胖相关的糖尿病相关的代谢物水平的改变。本文综述了代谢组学在阐明代谢物在肥胖和糖尿病相关的全身代谢调节中的作用方面所起的作用。并解释了这两种疾病之间可能的代谢关系和关联。对个体疾病中具有改变的代谢物谱以及两种疾病中特异性和相似改变的代谢物进行分类、归类和总结。
Obesity and diabetes arise from an intricate interplay between both genetic and environmental factors. It is well recognized that obesity plays an important role in the development of insulin resistance and diabetes. Yet, the exact mechanism of the connection between obesity and diabetes is still not completely understood. Metabolomics is an analytical approach that aims to detect and quantify small metabolites. Recently, there has been an increased interest in the application of metabolomics to the identification of disease biomarkers, with a number of well-known biomarkers identified. Metabolomics is a potent approach to unravel the intricate relationships between metabolism, obesity and progression to diabetes and, at the same time, has potential as a clinical tool for risk evaluation and monitoring of disease. Moreover, metabolomics applications have revealed alterations in the levels of metabolites related to obesity-associated diabetes. This review focuses on the part that metabolomics has played in elucidating the roles of metabolites in the regulation of systemic metabolism relevant to obesity and diabetes. It also explains the possible metabolic relation and association between the two diseases. The metabolites with altered profiles in individual disorders and those that are specifically and similarly altered in both disorders are classified, categorized and summarized.