Modelling and simulation techniques for membrane biology
Modelling and simulation techniques for membrane biology
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DOI：
10.1093/bib/bbm033
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发表时间：
2007-07-01
影响因子：
9.5
通讯作者：
Nicolau, Dan V., Jr.
中科院分区：
文献类型：
--
作者：
Burrage, Kevin;Hancock, John;Nicolau, Dan V., Jr.
计算细胞生物学最重要的方面之一是对发生在质膜上的复杂动力学过程的理解。这些过程通常是如此复杂，以至于纯粹的时间模型不能总是充分地捕捉动态。另一方面，空间模型可能有很大的计算开销。在本文中，我们回顾了化学、膜微畴和异常扩散方面的一些问题，并讨论了如何基于以下几个或所有方面选择适当的建模和模拟范式：离散、连续、随机、延迟和复杂空间过程。
One of the most important aspects of Computational Cell Biology is the understanding of the complicated dynamical processes that take place on plasma membranes. These processes are often so complicated that purely temporal models cannot always adequately capture the dynamics. On the other hand, spatial models can have large computational overheads. In this article, we review some of these issues with respect to chemistry, membrane microdomains and anomalous diffusion and discuss how to select appropriate modelling and simulation paradigms based on some or all the following aspects: discrete, continuous, stochastic, delayed and complex spatial processes.