Requirement of H‐2 heterozygosity for autoimmunity in (NZB × NZW)F1 hybrid mice
Requirement of H‐2 heterozygosity for autoimmunity in (NZB × NZW)F1 hybrid mice
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(NZB × NZW)F1 杂交小鼠自身免疫的 H−2 杂合性要求
DOI：
10.1002/eji.1830161226
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发表时间：
1986
影响因子：
5.4
通讯作者：
T. Shirai
中科院分区：
文献类型：
--
作者：
Short Paper;S. Hirose;G. Ueda;K. Noguchi;T. Okada;I. Sekigawa;H. Sato;T. Shirai
在自身免疫性新西兰黑（NZB）和表型正常的新西兰白（NZW）小鼠的F1杂交中，发生了严重的系统性红斑狼疮（SLE）样自身免疫性疾病，比亲本NZB小鼠更严重。为了确定H‐2复合物在（NZB × NZW）F1杂种自身免疫性疾病发病机制中的作用，我们开发了H‐2 -同源NZB （NZB.H‐2Z）和NZW （NZW.H‐2d）菌株，并比较了同源H‐2d/H‐2d和H‐2Z /H‐2Z纯合F1杂种和原始H‐2d/H‐2Z杂合（NZB × NZW）F1杂种之间的自身免疫性特征程度。我们发现，与H‐2杂合（NZB × NZW）F1杂交种相比，H‐2纯合F1杂交种的自身免疫特征，如IgG类抗DNA抗体和逆转录病毒gp70免疫复合物的产生以及肾脏疾病的发生在很大程度上减少了。由此看来，来自NZB的H‐2d单倍型和来自NZW的H‐2Z的杂合性对于（NZB × NZW）F1杂交的自身免疫性疾病特征是必不可少的。
In the F1 hybrid of autoimmune New Zealand Black (NZB) and phenotypically normal New Zealand White (NZW) mice, there occurs a severe systemic lupus erythematosus (SLE)‐like autoimmune disease more fulminant than that found in the parental NZB mice. To determine the role of the H‐2 complex in the pathogenesis of autoimmune disease of the (NZB × NZW)F1 hybrid, we developed H‐2‐congenic NZB (NZB.H‐2Z) and NZW (NZW.H‐2d) strains, and compared the degree of autoimmune features between congenic H‐2d/H‐2d and H‐2z/H‐2z homozygous F1 hybrids and the original H‐2d/H‐2z heterozygous (NZB × NZW)F1 hybrid. We found that autoimmune features such as productions of IgG class anti‐DNA antibodies and retroviral gp70 immune complexes and the development of renal disease were to a great extent reduced in both H‐2 homozygous F1 hybrids, as compared with the H‐2 heterozygous (NZB × NZW)F1 hybrid. It would thus appear that the heterozygosity of H‐2d haplotype derived from NZB and H‐2Z from NZW is essential for the autoimmune disease characteristic of the (NZB × NZW)F1 hybrid.