Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow
Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow
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DOI：
10.1038/s41551-018-0336-5
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发表时间：
2019-01-01
影响因子：
28.1
通讯作者：
Bao, Zhenan
中科院分区：
文献类型：
--
作者：
Boutry, Clementine M.;Beker, Levent;Bao, Zhenan
监测血流的能力对于复杂重建手术后的患者恢复和患者结局至关重要。临床上可用的有线植入式监测技术需要仔细固定以进行准确检测，并且在使用后需要移除。在这里，我们报告的压力传感器的设计，完全由可生物降解材料和边缘场电容器技术的基础上，用于测量动脉血流量在接触和非接触模式。该传感器通过感应耦合进行无线操作，具有最小的滞后、快速的响应时间、出色的循环稳定性、高度耐用、易于安装并无需拆卸，从而降低了血管创伤的风险。我们演示了操作的传感器与定制的人工动脉模型和在体内大鼠。该技术在重建手术后的血流的实时术后监测中可能是有利的。
The ability to monitor blood flow is critical to patient recovery and patient outcomes after complex reconstructive surgeries. Clinically available wired implantable monitoring technology requires careful fixation for accurate detection and needs to be removed after use. Here, we report the design of a pressure sensor, made entirely of biodegradable materials and based on fringe-field capacitor technology, for measuring arterial blood flow in both contact and non-contact modes. The sensor is operated wirelessly through inductive coupling, has minimal hysteresis, fast response times, excellent cycling stability, is highly robust, allows for easy mounting and eliminates the need for removal, thus reducing the risk of vessel trauma. We demonstrate the operation of the sensor with a custom-made artificial artery model and in vivo in rats. This technology may be advantageous in real-time post-operative monitoring of blood flow after reconstructive surgery.