Copeptin: A Novel, Independent Prognostic Marker in Patients with Ischemic Stroke
Copeptin: A Novel, Independent Prognostic Marker in Patients with Ischemic Stroke
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DOI：
10.1002/ana.21783
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发表时间：
2009-12-01
影响因子：
11.2
通讯作者：
Christ-Crain, Mirjam
中科院分区：
文献类型：
--
作者：
Katan, Mira;Fluri, Felix;Christ-Crain, Mirjam
目的：早期预测缺血性脑卒中患者的预后非常重要。加压素是一种应激激素。它的生产率反映在和肽素的循环水平上，和肽素是前加压素的一个片段。我们评估了和肽素在急性脑卒中patients.Methods的预后价值：在一项前瞻性观察性研究中，和肽素使用一种新的夹心免疫测定法测定入院时血浆中的362例连续急性缺血性脑卒中患者。和肽素对功能预后（定义为改良兰金量表评分≥ 3分）、90天内死亡率的预测价值，与美国国立卫生研究院卒中量表评分和其他已知的预后预测因子进行比较。
Objective: Early prediction of outcome in patients with ischemic stroke is important. Vasopressin is a stress hormone. Its production rate is mirrored in circulating levels of copeptin, a fragment of provasopressin. We evaluated the prognostic value of copeptin in acute stroke patients.Methods: In a prospective observational study, copeptin was measured using a new sandwich immunoassay on admission in plasma of 362 consecutive patients with an acute ischemic stroke. The prognostic value of copeptin to predict the functional outcome (defined as a modified Rankin Scale score of = 3), mortality within 90 days, was compared with the National Institutes of Health Stroke Scale score and with other known outcome predictors.Results: Patients with an unfavorable outcomes and nonsurvivors had significantly increased copeptin levels on admission (p