Synthesis of phase-pure and monodisperse iron oxide nanoparticles by thermal decomposition.
Synthesis of phase-pure and monodisperse iron oxide nanoparticles by thermal decomposition.
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DOI：
10.1039/c5nr01651g
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发表时间：
2015-07-07
期刊：
影响因子：
6.7
通讯作者：
Krishnan KM
中科院分区：
文献类型：
--
作者：
Hufschmid R;Arami H;Ferguson RM;Gonzales M;Teeman E;Brush LN;Browning ND;Krishnan KM
超顺磁性氧化铁纳米颗粒（SPION）用于广泛的生物医学应用，需要精确控制其物理和磁性，这取决于其尺寸和晶相。在这里，我们提出了一种用于设计和合成氧化铁纳米颗粒的综合模板，可以控制尺寸、尺寸分布、相和由此产生的磁性能。我们研究了有机热分解法合成单分散SPION的关键参数。三种不同的，常用的，含铁的前体（油酸铁，五羰基铁，和羟基氧化铁）在各种合成条件下进行评估。我们比较了这三种动力学控制的合成方案的适用性，这些方案共同使用油酸铁作为起始前体或反应中间体，用于生产具有特定尺寸和磁性的纳米颗粒。在约2-30 nm的可调尺寸范围内产生单分散颗粒。反应参数，如前体浓度，添加表面活性剂，温度，斜坡速率，和时间进行调整，动力学控制的大小和大小分布，相，和磁性。特别是，大量过量的表面活性剂（高达25：1摩尔比）改变反应动力学，并导致具有均匀尺寸的较大颗粒;然而，通常在大颗粒和窄尺寸分布之间存在权衡。除了纳米颗粒的尺寸和形状之外，氧化铁相对于建立磁特性如微分磁化率（dm/dH）和各向异性是至关重要的。作为一个例子，我们得到所需的大小和氧化铁相的应用磁粒子成像（MPI）的重要性，并描述如何相纯度可以控制。这些结果提供了确定哪种氧化铁合成方案最适合于特定应用所需的许多信息。
Superparamagnetic iron oxide nanoparticles (SPIONs) are used for a wide range of biomedical applications requiring precise control over their physical and magnetic properties, which are dependent on their size and crystallographic phase. Here we present a comprehensive template for the design and synthesis of iron oxide nanoparticles with control over size, size distribution, phase, and resulting magnetic properties. We investigate critical parameters for synthesis of monodisperse SPIONs by organic thermal decomposition. Three different, commonly used, iron containing precursors (iron oleate, iron pentacarbonyl, and iron oxyhydroxide) are evaluated under a variety of synthetic conditions. We compare the suitability of these three kinetically controlled synthesis protocols, which have in common the use of iron oleate as a starting precursor or reaction intermediate, for producing nanoparticles with specific size and magnetic properties. Monodisperse particles were produced over a tunable range of sizes from approximately 2–30 nm. Reaction parameters such as precursor concentration, addition of surfactant, temperature, ramp rate, and time were adjusted to kinetically control size and size-distribution, phase, and magnetic properties. In particular, large quantities of excess surfactant (up to 25:1 molar ratio) alter reaction kinetics and result in larger particles with uniform size; however, there is often a trade-off between large particles and a narrow size distribution. Iron oxide phase, in addition to nanoparticle size and shape, is critical for establishing magnetic properties such as differential susceptibility (dm/dH) and anisotropy. As an example, we show the importance of obtaining the required size and iron oxide phase for application to Magnetic Particle Imaging (MPI), and describe how phase purity can be controlled. These results provide much of the information necessary to determine which iron oxide synthesis protocol is best suited to a particular application.
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影响因子：
14
作者：
Arami, Hamed;Khandhar, Amit P.;Tomitaka, Asahi;Yu, Elaine;Goodwill, Patrick W.;Conolly, Steven M.;Krishnan, Kannan M.
通讯作者：
Krishnan, Kannan M.
影响因子：
15
作者：
Hyeon, T;Lee, SS;Bin Na, H
通讯作者：
Bin Na, H
影响因子：
15.6
作者：
KAHLWEIT, M
通讯作者：
KAHLWEIT, M
影响因子：
9.9
作者：
Hai, Hoang Tri;Kura, Hiroaki;Ogawa, Tomoyuki
通讯作者：
Ogawa, Tomoyuki
影响因子：
16.6
作者：
Ge, Jianping;Hu, Yongxing;Yin, Yadong
通讯作者：
Yin, Yadong