Four New Steroidal Saponins from the Rhizomes of Helleborus orientalis
Four New Steroidal Saponins from the Rhizomes of Helleborus orientalis
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DOI：
10.3987/com-04-10319
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发表时间：
2005-04
期刊：
影响因子：
0.6
通讯作者：
Kazuki Watanabe;H. Sakagami;Y. Mimaki
中科院分区：
文献类型：
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作者：
Kazuki Watanabe;H. Sakagami;Y. Mimaki
对铁东方根茎的甲醇提取物的富含糖苷部分进行了植物化学分析，结果分离出两种新的双链呋甾烷醇皂苷（1 和 2）和两种新的呋喃甾烷醇皂苷（3 和 4）。 1-4的结构是在广泛的光谱分析和酸水解以及随后的色谱和光谱分析的基础上确定的。化合物(3)对HSC-2人鳞状细胞癌细胞表现出中等的细胞毒活性，IC 5 0 值为16μg/mL。
A phytochemical analysis has been carried out on the glycoside-enriched fraction of a MeOH extract of Helleborus orientalis rhizomes, resulting in the isolation of two new bisdesmosidic furostanol saponins (1 and 2) and two new furospirostanol saponins (3 and 4). The structures of 1-4 were determined on the basis of extensive spectroscopic analysis and acid hydrolysis followed by chromatographic and spectroscopic analysis. Compound (3) showed moderate cytotoxic activity against HSC-2 human squamous cell carcinoma cells with an IC 5 0 value of 16 μg/mL.