Core neurocognitive functions in children treated for posterior fossa tumors
Core neurocognitive functions in children treated for posterior fossa tumors
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DOI：
10.1037/0894-4105.22.2.159
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发表时间：
2008-03-01
期刊：
影响因子：
2.4
通讯作者：
Bouffet, Eric
中科院分区：
文献类型：
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作者：
Mabbott, Donald J.;Witol, Adrienne;Bouffet, Eric
识别与儿童脑肿瘤相关的认知缺陷及其治疗对于描述通常与这些疾病相关的智力下降机制非常重要。作者评估了 64 名后颅窝肿瘤患者的持续注意力、信息处理速度、工作记忆和智商，其中包括接受以下治疗的患者：(a) 手术和颅脑放射治疗 (n = 32)，以及 (b) 不进行放射治疗的手术 (n. = 32)。十名接受非中枢神经系统实体瘤治疗的患者被纳入对照组。作者还研究了相关人口和医学变量对神经认知结果的影响。作者发现，诊断时的年龄和诊断后的时间都不能预测该样本的认知结果。此外，持续注意力和工作记忆基本完好，组间没有差异。接受颅脑放射治疗的患者表现出短期智商降低和信息处理速度缓慢：接受颅脑放射治疗且经历术后并发症的患者表现出最差的表现。作者认为信息处理速度是理解颅脑辐射对智力结果影响的绝佳候选机制。
Identifying cognitive deficits associated with pediatric brain tumors and their treatment is important in delineating the mechanisms of intellectual decline often associated with these diseases. The authors evaluated sustained attention, information processing speed, working memory, and IQ in 64 patients with posterior fossa tumors, including those treated with either: (a) surgery and cranial radiation (n = 32), and (b) surgery without radiation (n. = 32). Ten patients treated for non-CNS solid tumors were included as a comparison group. The authors also examined the impact of relevant demographic and medical variables on neurocognitive outcome. The authors found that neither age at, nor time since, diagnosis predicted cognitive outcome in this sample. Further, sustained attention and working memory were largely intact and there were no differences between groups. Patients treated with cranial radiation demonstrated lowered short-form IQ and slow information processing speed: Patients treated with cranial radiation and who experienced postsurgical complications demonstrated the poorest performance. The authors consider information processing speed to be an excellent candidate mechanism in understanding the impact of cranial radiation on intellectual outcome.