Therapeutic amenorrhea in patients at risk for thrombocytopenia
Therapeutic amenorrhea in patients at risk for thrombocytopenia
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DOI：
10.1097/ogx.0b013e3181706620
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发表时间：
2008-06-01
影响因子：
6.2
通讯作者：
Armstrong, Alicia
中科院分区：
文献类型：
--
作者：
Martin-Johnston, Meredith K.;Okoji, Olanma Y.;Armstrong, Alicia
探讨有血小板减少危险的妇女月经抑制的必要性和评价方法。对MEDLINE上发表的搜索词为血小板减少、月经过多、治疗性闭经、黄体酮宫内节育器、复方口服避孕药和循环避孕药、促性腺激素释放激素激动剂、那那唑和黄体酮的文献进行系统回顾。有越来越多的育龄妇女有患血小板减少症的危险，她们可以从月经抑制中获益。有一些有效的医疗方案。在药物治疗失败的患者中，子宫内膜消融似乎对患有血小板减少症的女性有效。由于有血小板减少危险的妇女人数增加，需要治疗性闭经。所选择的方案类型取决于患者对避孕的需要和对含雌激素药物的耐受能力。对于药物治疗失败的妇女，有手术选择，其发病率比子宫切除术低。
To examine the need for and evaluate the method of menses suppression in women at risk for thrombocytopenia. A systematic review of the published literature in MEDLINE using the search terms thrombocytopenia, menorrhagia, therapeutic amenorrhea, progestin intrauterine device, combination oral contraceptive-extended and cyclic, gonadotropin releasing hormone agonist, danazol, and progestins. There are an increased number of reproductive age women at risk for thrombocytopenia who would benefit from menses suppression. A number of effective medical regimens are available. In patients who fail medical therapy, endometrial ablation appears to be effective in women with thrombocytopenia. As a result of the increased number of women at risk for thrombocytopenia, there is a need for therapeutic amenorrhea. The type of regimen selected depends upon the patients need for contraception and the ability to tolerate estrogen-containing medications. For women who fail medical therapy, there are surgical options, which are associated with less morbidity than hysterectomy.