Assessment of airway responsiveness in infants with cystic fibrosis.
Assessment of airway responsiveness in infants with cystic fibrosis.
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囊性纤维化婴儿气道反应性的评估。
DOI：
10.1164/ajrccm/144.2.344
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Tepper,RS
中科院分区：
文献类型：
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作者：
Ackerman,V;Montogomery,G;Eigen,H;Tepper,RS
我们比较了囊性纤维化（CF）（N = 14）和正常（N = 14）婴儿吸入乙酰甲胆碱的反应。通过快速按压技术产生的功能残气量（最大FRC）下的用力呼气流量评估气道功能，乙酰甲胆碱反应性定量为（1）TC：最大FRC从基线降低2 SD的阈值浓度;（1）PC 30：最大FRC降低30%的激发浓度;（3）SPC 30：TC和PC之间的剂量反应曲线的斜率30。CF组与正常组婴儿年龄无显著性差异（16 ± 8 vs 17 ± 5个月，p > 0.3）;然而，CF婴儿较短，（74 ± 10 vs 81 ± 5 cm，p < 0.05），绝对最大FRC较低（241 ± 103对374 ± 113 ml/s，p < 0.001），并且倾向于具有较低的预测流量值百分比（87 ± 13对111 ± 34%，p < 0.10）。气道反应性指数的比较显示logTC没有差异;然而，CF婴儿的logPC 30更小，负值更大（-0.76 ± 0.52 vs-0.22 ± 0.53，p < 0.02），剂量反应曲线的斜率更陡（logSPC 30，2.42 ± 0.45 vs 1.88 ± 0.74，p < 0.025）。气道反应性指数与基线最大FRC（占预测值的%）显著相关。在通过多元线性回归分析基线流量对气道反应性的影响后，CF婴儿比对照婴儿有更敏感的趋势。我们的结论是，与正常年龄匹配的对照组婴儿相比，我们的CF婴儿有更高的乙酰甲胆碱反应性;然而，反应性的差异主要与CF婴儿具有较低的基线流量有关。
We compared the responses of cystic fibrosis (CF) (N = 14) and normal (N = 14) infants with inhaled methacholine. Airway function was assessed by forced expiratory flows at functional residual capacity (max FRC) generated by the rapid compression technique, and methacholine responsiveness was quantitated as (1) TC: the threshold concentration to decrease max FRC by 2 SD from baseline; (1) PC30: the provocative concentration to decrease max FRC by 30%; and (3) SPC30: the slope of the dose-response curve between TC and PC30. There were no significant differences in age between CF and normal infants (16 ± 8 versus 17 ± 5 months, p > 0.3); however, the CF infants were shorter (74 ± 10 versus 81 ± 5 cm, p < 0.05), had lower absolute max FRC (241 ± 103 versus 374 ± 113 ml/s, p < 0.001), and tended to have lower percentage of predicted flow values (87 ± 13 versus 111 ± 34%, p < 0.10). Comparison of the indices of airway responsiveness revealed no difference in logTC; however, the CF infants had smaller, more negative values for logPC30(−0.76 ± 0.52 versus −0.22 ± 0.53, p < 0.02) and steeper slopes to their dose-response curves (logSPC30, 2.42 ± 0.45 versus 1.88 ± 0.74, p < 0.025). Indices of airway responsiveness correlated significantly with baseline max FRC (% of predicted). After the influence of baseline flow upon airway responsiveness was accounted for by multiple linear regression analysis, there was a tendency for CF infants to be more responsive than control infants. We concluded that our infants with CF had heightened methacholine responsiveness compared with normal age-matched control infants; however, the difference in responsiveness was primarily related to CF infants having lower baseline flows.