Noncovalently Assembled Electroconductive Hydrogel.
Noncovalently Assembled Electroconductive Hydrogel.
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DOI：
10.1021/acsami.8b01029
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发表时间：
2018-04
影响因子：
9.5
通讯作者：
Yong Xu;Xuegeng Yang;Alvin K. Thomas;P. A. Patsis;T. Kurth;M. Kräter;K. Eckert;M. Bornhäuser;Yixin Zhang
中科院分区：
文献类型：
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作者：
Yong Xu;Xuegeng Yang;Alvin K. Thomas;P. A. Patsis;T. Kurth;M. Kräter;K. Eckert;M. Bornhäuser;Yixin Zhang
通过非共价相互作用将生物分子与导电纳米结构进行交联，可以形成具有特定生物功能和物理性质的模块化网络，如导电性和粘弹性。此外，所得到的矩阵可以表现出由动态组装过程引起的有趣的特征，例如自我修复和分子有序化。在本文中，我们提出了一种由多肽-聚乙二醇和聚(3，4-乙二氧基噻吩基)：聚苯乙烯磺酸形成的物理水凝胶体系。这种组合方法使用不同的模块构建块，可以在流变学和电阻抗方面实现高可调性。所提出的物理水凝胶系统的特点是具有自我愈合能力和可注射性。有趣的是，在相对较低的浓度下形成的水凝胶导致了聚(3，4-乙二氧基噻吩基)纳米颗粒更紧密的分子堆积网络，这反映在增强的电导率上。该生物聚合物体系可用于三维细胞培养中加入电刺激，其对被包裹的间充质基质细胞的存活和增殖以及电刺激下的分化的贡献证明了这一点。
Cross-linking biomolecules with electroconductive nanostructures through noncovalent interactions can result in modular networks with defined biological functions and physical properties such as electric conductivity and viscoelasticity. Moreover, the resulting matrices can exhibit interesting features caused by the dynamic assembly process, such as self-healing and molecular ordering. In this paper, we present a physical hydrogel system formed by mixing peptide-polyethylene glycol and poly(3,4-ethylenedioxythiophene):polystyrene sulfonate. This combinatorial approach, which uses different modular building blocks, could lead to high tunability on aspects of rheology and electrical impedance. The proposed physical hydrogel system is characterized by both a self-healing ability and injectability. Interestingly, the formation of hydrogels at relatively low concentrations led to a network of closer molecular packing of poly(3,4-ethylenedioxythiophene) nanoparticles, reflected by the enhanced conductivity. The biopolymer system can be used to develop three-dimensional cell cultures with incorporated electric stimuli, as evidenced by its contribution to the survival and proliferation of encapsulated mesenchymal stromal cells and their differentiation upon electrical stimulation.