Effects of haloperidol on sensory processing in the hippocampus during classical eyeblink conditioning.
Effects of haloperidol on sensory processing in the hippocampus during classical eyeblink conditioning.
复制标题
氟哌啶醇对经典眨眼条件反射过程中海马感觉处理的影响。
DOI：
10.1007/s002130050237
复制
发表时间：
1997
影响因子：
3.4
通讯作者：
Steinmetz,JE
中科院分区：
文献类型：
--
作者：
Sears,LL;Steinmetz,JE
采用家兔经典眨眼条件反射实验范式，观察氟哌啶醇对海马功能的影响。氟哌啶醇干扰海马活动和条件反应（CR）在低，但不高条件刺激（CS）强度。观察到的海马活动和CR的关系表明，海马编码与学习反应相关的感觉功能。海马的感觉处理似乎被氟哌啶醇通过CS引起学习反应的能力的衰减而改变。结果进行了讨论，在感觉处理和可能的机制氟哌啶醇在精神分裂症的有益影响海马的作用。经典的眨眼条件反射可能为研究精神分裂症的病因学和治疗相关的行为和生物学问题提供了一个模型系统。
The rabbit classical eyeblink conditioning paradigm was used to assess the effects of haloperidol on hippocampal function. Haloperidol disrupted hippocampal activity and conditioned responses (CRs) at low but not high conditioned stimulus (CS) intensities. The observed relationship of hippocampal activity and the CR suggested that the hippocampus encoded sensory features associated with the learned response. Sensory processing by the hippocampus appeared to be altered by haloperidol through attenuation of the ability of a CS to evoke a learned response. Results are discussed in terms of the role of the hippocampus in sensory processing and possible mechanisms for the beneficial effects of haloperidol in schizophrenia. Classical eyeblink conditioning may provide a model system for studying behavioral and biological issues relevant to the etiology and treatment of schizophrenia.