Effects of Black Raspberry on Lipid Profiles and Vascular Endothelial Function in Patients with Metabolic Syndrome
Effects of Black Raspberry on Lipid Profiles and Vascular Endothelial Function in Patients with Metabolic Syndrome
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DOI：
10.1002/ptr.5154
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发表时间：
2014-10-01
影响因子：
7.2
通讯作者：
Lim, Do-Sun
中科院分区：
文献类型：
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作者：
Jeong, Han Saem;Hong, Soon Jun;Lim, Do-Sun
黑覆盆子（Rubus occidentalis）以其抗炎和抗氧化作用而闻名。然而，黑覆盆子对代谢综合征患者血脂和血管内皮功能的短期影响尚未被研究。在为期12周的随访期间，代谢综合征患者（n=77）前瞻性随机分为黑覆盆子组（n=39, 750mg/天）和安慰剂组（n=38）。在基线和12周随访时测量脂质谱、肱动脉血流介导扩张（baFMD）和炎症细胞因子如IL-6、TNF-、c反应蛋白、脂联素、sICAM-1和sVCAM-1。总胆固醇水平较基线降低(-22.8 +/- 30.4mg/dL vs -1.9 +/- 31.8mg/dL, p
Black raspberry (Rubus occidentalis) has been known for its anti-inflammatory and anti-oxidant effects. However, short-term effects of black raspberry on lipid profiles and vascular endothelial function have not been investigated in patients with metabolic syndrome. Patients with metabolic syndrome (n=77) were prospectively randomized into a group with black raspberry (n=39, 750mg/day) and a placebo group (n=38) during a 12-week follow-up. Lipid profiles, brachial artery flow-mediated dilatation (baFMD), and inflammatory cytokines such as IL-6, TNF-, C-reactive protein, adiponectin, sICAM-1, and sVCAM-1 were measured at the baseline and at the 12-week follow-up. Decreases from the baseline in the total cholesterol level (-22.8 +/- 30.4mg/dL vs. -1.9 +/- 31.8mg/dL, p