Different segmental transit times in patients with irritable bowel syndrome and "normal" colonic transit time: is there a correlation with symptoms?
Different segmental transit times in patients with irritable bowel syndrome and "normal" colonic transit time: is there a correlation with symptoms?
复制标题
DOI：
10.1007/s10151-006-0295-9
复制
发表时间：
2006-12-01
影响因子：
3.3
通讯作者：
Arsac, M
中科院分区：
文献类型：
--
作者：
Bouchoucha, M;Devroede, G;Arsac, M
背景技术背景：罗马标准作为建立肠易激综合征（IBS）诊断的金标准，但仅代表一组症状。另一方面，使用不透射线标记物测量结肠通过时间（CTT）是一种可靠且更客观的方法，可用于量化功能异常。本研究的目的是调查是否IBS症状，定义在罗马II标准，对应于客观的生理参数，即CCT。方法：该研究纳入了148名健康对照组和1385连续IBS患者。测量了整个直肠结肠（整体CTT）和3个节段（右结肠、左结肠、直肠乙状结肠区）的通过时间;还评估了标记物的节段分布和扩散系数。为了分析同质组，我们将分析限制在CTT“正常”（<或=70 h）的受试者。结果：644例IBS患者（46%）和14例对照受试者（9%）的CTT >70 h并被排除。在CTT <或=70 h的受试者中，CTT不遵循正态（高斯）分布。我们在健康对照中确定了3个不同的CTT簇，在IBS患者中确定了4个簇。即使CTT没有显着不同的集群，每个集群的特点是一个特定的模式，节段性结肠运输。有明显的性别差异：在对照组和IBS患者组中，女性的总CTT值均长于男性（p
BACKGROUND: The Rome criteria serve as gold standard for establishing a diagnosis of irritable bowel syndrome (IBS), but only represent a cluster of symptoms. On the other hand, measurement of colonic transit time (CTT) with radiopaque markers is a solid and more objective method to quantify functional abnormalities. The goal of this study was to investigate whether the IBS symptoms, as defined in the Rome II criteria, correspond to objective physiological parameters, i.e. CCTs.METHODS: The study enrolled 148 healthy control subjects and 1385 consecutive IBS patients. Transit times were measured for the whole rectocolon (overall CTT) and for 3 segments (right colon, left colon, rectosigmoid area); segmental distribution of markers and diffusion coefficients were also assessed. In order to analyze homogeneous groups, we restricted analysis to subjects with "normal" CTT (< or =70 hours).RESULTS: Six hundred forty four IBS patients (46%) and 14 control subjects (9%) had CTT >70 h and were eliminated. In subjects with CTT < or =70 h, CTT did not follow a normal (Gaussian) distribution. We identified 3 different CTT clusters in healthy controls and 4 clusters in IBS patients. Even if CTT was not significantly different between clusters, each cluster was characterized by a specific pattern of segmental colonic transit. There was a marked gender difference: women had longer overall CTT values than men, both in control and IBS patient groups (p