Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains
Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains
复制标题
DOI：
10.1016/j.nbd.2006.12.017
复制
发表时间：
2007-04-01
影响因子：
6.1
通讯作者：
Cotman, Carl W.
中科院分区：
文献类型：
--
作者：
Christie, Lori-Ann;Su, Joseph H.;Cotman, Carl W.
与细胞凋亡相关的神经元变性可以被称为细胞凋亡抑制蛋白（IAP）的蛋白质家族抑制。我们研究了IAP家族的三个成员，它们与神经元死亡的调节有关。我们评估了非痴呆、认知障碍和阿尔茨海默病病例的内嗅皮层中NAIP、XIAP和cIAP-2蛋白水平。评估成对螺旋丝-1（PHF-1）的水平（神经元缠结的标志物），以确定其与IAP水平的关系。与轻度受损和未受损病例相比，AD病例中NAIP降低，并且这种降低与PHF-1水平升高相关。低NAIP水平与较高的Braak和Braak缠结阶段和认知功能障碍相关。XIAP水平在AD病例中较高，cIAP-2水平不随临床状态而变化。我们的数据表明，NAIP降低可能会使神经元处于缠结和凋亡的危险之中。(c)2006年爱思唯尔公司All rights reserved.
Neuronal degeneration linked to apoptosis can be inhibited by a family of proteins known as inhibitors of apoptosis proteins (IAPs). We examined three members of the IAP family that are implicated in the regulation of neuronal death. We assessed NAIP, XIAP, and cIAP-2 protein levels in the entorhinal cortex of non-demented, cognitively impaired and Alzheimer's disease cases. Levels of paired helical filament-1 (PHF-1), a marker of neurofibrillary tangles, were assessed to determine their relationship to IAP levels. NAIP was decreased in AD cases compared to mildly impaired and unimpaired cases, and this decrease was associated with increased PHF-1 levels. Low NAIP levels were associated with higher Braak and Braak tangle stage and cognitive dysfunction. XIAP levels were higher in AD cases and cIAP-2 levels did not vary with clinical status. Our data suggest that decreased NAIP may place neurons at risk for the development of tangles and apoptosis. (c) 2006 Elsevier Inc. All rights reserved.