Evolution of metabolic networks by gain and loss of enzymatic reaction in eukaryotes.
Evolution of metabolic networks by gain and loss of enzymatic reaction in eukaryotes.
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DOI：
10.1016/j.gene.2005.09.030
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发表时间：
2006-01
期刊：
影响因子：
3.5
通讯作者：
Tsuyoshi Tanaka;K. Ikeo;T. Gojobori
中科院分区：
文献类型：
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作者：
Tsuyoshi Tanaka;K. Ikeo;T. Gojobori
代谢网络是由一种或多种酶催化相关底物的酶促反应（er）组成的。由于新陈代谢是维持所有生物体生命的基础系统，新陈代谢网络的任何变化都必然对生物体的进化产生重大影响。本研究的目的是研究在真核生物代谢网络的进化过程中，内质网的获得和损失发生的频率，以及这些进化事件如何影响生物体的表型性状。在这项研究中，我们对6种真核生物代谢网络中的751个er进行了比较研究，并确定了它们的全基因组序列。结果，我们发现在不同谱系的代谢网络的进化多样化中，共发生了804个er的增益和损失。此外，在与黑腹果蝇分离后，脊椎动物谱系的内质网增益比内质网损失显著增加。特别是，41%的内质网增加主要与脂质和复杂脂质代谢有关。由于这两种代谢的一些产物具有激素的功能，我们得出结论，这两种代谢的ER增益加速了激素信号转导的发展，从而在脊椎动物进化过程中对生理系统进行精细调节。
The metabolic network is composed of enzymatic reactions (ERs) in which one or more enzymes catalyze the reaction of pertinent substrates. Since metabolism is a basal system for maintaining life of all organisms, any change in the metabolic networks must greatly affect organismic evolution. The aim of this study is to examine how often gains and losses of ER have occurred during the evolution of metabolic networks in eukaryotes and how these evolutionary events have affected phenotypic traits of organisms. In this study, we conducted comparative studies of 751 ERs in the metabolic networks of 6 eukaryotic species whose complete genome sequences were determined. As a result, we found that a total of 804 gains and losses of ERs had occurred in the evolutionary diversification of metabolic networks in different lineages. Moreover, the vertebrate lineage, after the separation from Drosophila melanogaster, showed a remarkable increase in the number of ER gains compared with ER losses. In particular, 41% of the ER gains were predominantly involved with lipids and complex lipid metabolism. Because some products of these two metabolisms function as hormones, we concluded that the ER gain of these two metabolisms accelerated the development of hormonal signal transduction for the elaborate regulation of physiological systems during vertebrate evolution.