Host restriction of Friend leukemia virus: gag proteins of host range variants.
Host restriction of Friend leukemia virus: gag proteins of host range variants.
复制标题
Friend白血病病毒的宿主限制：宿主范围变体的gag蛋白。
DOI：
10.1073/pnas.78.4.2320
复制
发表时间：
1981
影响因子：
11.1
通讯作者：
Soeiro,R
中科院分区：
文献类型：
--
作者：
Duttagupta,S;Soeiro,R
The host response to murine ecotropic leukemia viruses is mainly controlled by the mouse Fv-1 gene. This locus controls virus replication at an intracellular stage and prevents provirus integration. Biological studies suggest that the Fv-1 effector molecule recognizes at least one virion structural protein. We have produced host range variants of B-tropic Friend murine leukemia virus in order to study the primary structure of potential viral target proteins. Our results show that conversion of B-tropism to NB-tropism is associated with changes in the primary structure of three gag proteins--p15, p12, and p30. These results suggest that host range conversion is due to a recombinational event, presumably between the parental virus and an endogenous murine virus. They also open the possibility that p12 and p30 may be involved in host range restriction.
