STRESS-INDUCED MODULATION OF THE IMMUNE-RESPONSE TO RECOMBINANT HEPATITIS-B VACCINE
STRESS-INDUCED MODULATION OF THE IMMUNE-RESPONSE TO RECOMBINANT HEPATITIS-B VACCINE
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DOI：
10.1097/00006842-199201000-00005
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发表时间：
1992-01-01
影响因子：
3.3
通讯作者：
HUGHES, J
中科院分区：
文献类型：
--
作者：
GLASER, R;KIECOLTGLASER, JK;HUGHES, J
在为期3天的系列检查的第3天，对48名二年级医学生进行了3次B型肝炎（Hep B）接种，以研究学业压力对产生对初级抗原的免疫应答能力的影响。那些在第一次注射后血清转化的学生（25%）的压力和焦虑明显低于那些当时没有血清转化的学生。此外，报告社会支持更大的学生在第三次接种时表现出更强的疫苗免疫应答，通过对B肝炎表面抗原（HBsAg）的抗体滴度和对HBsAg肽（SAg）的母细胞生成应答来测量。
Each of a series of three hepatitis B (Hep B) inoculations was given to 48 second-year medical students on the 3rd day of a 3-day examination series to study the effect of academic stress on the ability to generate an immune response to a primary antigen. Those students who seroconverted after the first injection (25%) were significantly less stressed and anxious than those who did not seroconvert at that time. In addition, students who reported greater social support demonstrated a stronger immune response to the vaccine at the time of the third inoculation, as measured by antibody titers to Hep B surface antigen (HBsAg) and the blastogenic response to a HBsAg peptide (SAg).