The Conserved Role of YidC in Membrane Protein Biogenesis.
The Conserved Role of YidC in Membrane Protein Biogenesis.
复制标题
DOI：
10.1128/microbiolspec.psib-0014-2018
复制
发表时间：
2019-01
影响因子：
3.7
通讯作者：
Sri Karthika Shanmugam;R. Dalbey
中科院分区：
文献类型：
--
作者：
Sri Karthika Shanmugam;R. Dalbey
摘要YidC插入酶在许多蛋白质的膜整合、折叠和组装中起着关键作用，包括能量转导呼吸复合物，无论是自主的还是与细菌中的SecYEG通道一致。YidC蛋白家族在生命的所有领域中广泛保守，最近在真核内质网膜中发现了新成员。细菌和细胞器成员共享保守的5-跨膜核心，其在可从细胞质和脂质相进入的双层的内小叶中形成独特的亲水腔。在这一章中，我们讨论了YidC家族的蛋白质，专注于其机制的基板插入独立和关联的Sec translocon。
ABSTRACT YidC insertase plays a pivotal role in the membrane integration, folding, and assembly of a number of proteins, including energy-transducing respiratory complexes, both autonomously and in concert with the SecYEG channel in bacteria. The YidC family of proteins is widely conserved in all domains of life, with new members recently identified in the eukaryotic endoplasmic reticulum membrane. Bacterial and organellar members share the conserved 5-transmembrane core, which forms a unique hydrophilic cavity in the inner leaflet of the bilayer accessible from the cytoplasm and the lipid phase. In this chapter, we discuss the YidC family of proteins, focusing on its mechanism of substrate insertion independently and in association with the Sec translocon.