Graft failure in the modern era of allogeneic hematopoietic SCT

Graft failure in the modern era of allogeneic hematopoietic SCT
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DOI:
10.1038/bmt.2012.239
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发表时间:
2013-04-01
影响因子:
4.8
通讯作者:
Ringden, O.
Ringden, O.
中科院分区:
医学3区
文献类型:
--
作者:
Olsson, R.;Remberger, M.;Ringden, O.

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移植失败可能导致异基因造血干细胞移植(allo-HSCT)后发病率和死亡率增加。在这里,我们介绍了从1995年到2010年中期在我们中心进行的所有首次allo-HSCT中移植失败的风险因素(n=967)。移植失败定义为移植后任何时间>95%的受体细胞没有复发的迹象,或由于原发性或继发性中性粒细胞减少而再次移植。
Graft failure may contribute to increased morbidity and mortality after allogeneic hematopoietic SCT (allo-HSCT). Here, we present risk factors for graft failure in all first allo-HSCTs performed at our center from 1995 to mid-2010 (n=967). Graft failure was defined as >95% recipient cells any time after engraftment with no signs of relapse, or re-transplantation because of primary or secondary neutropenia (