Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs.
Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs.
复制标题
瘤床X射线照射对肿瘤血流和血管对药物反应的影响。
DOI：
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复制
发表时间：
1978
影响因子：
8.8
通讯作者：
K. H. Clifton
中科院分区：
文献类型：
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作者：
R. Jirtle;J. Rankin;K. H. Clifton
先前暴露于 1500 R X 射线的大鼠乳腺中生长的肿瘤的血流量是未照射宿主组织中相同大小肿瘤的 52%。照射后约2个月，与相应的未照射组织相比，乳腺的血流量增加，而皮肤的血流量没有变化。在预照射和未照射的乳腺中生长的肿瘤与推注去甲肾上腺素、血管紧张素 II 和异丙肾上腺素的反应相似。然而，受辐射组织对这些药物的反应并不总是与相应的未受辐射组织相同。肺部暴露于大约 1500 R X 射线下，使动物对去甲肾上腺素和血管紧张素 II 的推注特别敏感。
The blood flow of tumours growing in rat mammary glands previously exposed to 1500 R X-rays was 52% that of same-sized tumours in unirradiated host tissue. About 2 months after irradiation, the blood flow of the mammary gland was raised and that of the skin was unchanged, compared with the corresponding unirradiated tissue. Tumours growing in preirradiated and unirradiated mammary glands responded similarly to bolus injections of noradrenaline, angiotensin II, and isoprenaline. The responses of the irradiated tissues to these drugs were, however, not always the same as those of the corresponding unirradiated tissues. Exposure of the lungs to approximately 1500 R X-rays made the animals uniquely sensitive to bolus injections of noradrenaline and angiotensin II.