Evaluation of 18F-FDG uptake for detecting lymph node metastasis of gastric cancer: a prospective pilot study for one-to-one comparison of radiation dose and pathological findings.
Evaluation of 18F-FDG uptake for detecting lymph node metastasis of gastric cancer: a prospective pilot study for one-to-one comparison of radiation dose and pathological findings.
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DOI：
10.1186/s12957-015-0743-y
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发表时间：
2015-12-02
影响因子：
3.2
通讯作者：
Seto Y
中科院分区：
文献类型：
--
作者：
Okumura Y;Aikou S;Onoyama H;Jinbo K;Yamagata Y;Mori K;Yamashita H;Nomura S;Takahashi M;Koyama K;Momose T;Abe H;Matsusaka K;Ushiku T;Fukayama M;Seto Y
胃癌在正电子发射断层扫描/计算机断层扫描（PET/CT）上表现出不同程度的氟-18氟脱氧葡萄糖（18F-FDG）摄取。我们评估了18F-FDG摄取与单个淋巴结（LN）转移的存在/不存在之间的关系。我们分析了21例胃癌患者。我们在上午静脉注射18F-FDG，并在当天下午进行胃切除术和LN剥离。用井式计数器测量各淋巴结的放射剂量，比较各淋巴结的18F-FDG摄取、最短径和病理检查结果。在我们的研究中，分析了906个淋巴结，包括115个转移性淋巴结。转移淋巴结18F-FDG摄取明显增高（P < 0.0001），淋巴结明显增大（P < 0.0001）。受试者工作特征（ROC）曲线中，18F-FDG摄取的曲线下面积（0.71）大于最短LN直径的曲线下面积（0.60）。肠型腺癌的ROC曲线下面积大于弥漫型腺癌（0.75 vs 0.61）。F-FDG摄取可能是一个比LN直径更有用的变量，用于区分LN有无转移，特别是在肠型胃癌病例中。
Gastric cancer exhibits various degrees of fluorine F-18 fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography/computed tomography (PET/CT). We evaluated the relationship between 18F-FDG uptake and the presence/absence of metastasis in individual lymph nodes (LN) on a one-to-one basis. We analyzed 21 patients with gastric cancer. We injected 18F-FDG intravenously in the morning, and gastrectomy with LN dissection was performed in the afternoon of the same day. Radiation doses were measured at each LN using a well-type counter, and we then compared 18F-FDG uptake, the shortest diameter, and pathological examination results for each LN. In our study, 906 LNs were analyzed, including 115 metastatic LNs. Metastatic LNs showed significantly higher 18F-FDG uptake (P < 0.0001), and were significantly enlarged (P < 0.0001). The receiver operating characteristics (ROC) curve had a larger area under the curve (0.71) for 18F-FDG uptake than for the shortest LN diameter (0.60). Considering histology, the ROC curve for intestinal type adenocarcinoma had a larger area under the curve than that for diffuse type (0.75 vs 0.61). F-FDG uptake is potentially a more useful variable than LN diameter for discriminating between LN with and without metastasis, especially in intestinal type gastric cancer cases.