Comparison of different kinetic models for dynamic 18F-FDG PET/CT imaging of hepatocellular carcinoma with various, also dual-blood input function
Comparison of different kinetic models for dynamic 18F-FDG PET/CT imaging of hepatocellular carcinoma with various, also dual-blood input function
复制标题
不同双血输入功能的肝细胞癌动态F-18-FDG PET/CT成像不同动力学模型的比较
DOI：
10.1088/1361-6560/ab66e3
复制
发表时间：
2020-02-01
影响因子：
3.5
通讯作者：
Li, Xiang
中科院分区：
文献类型：
--
作者：
Geist, Barbara Katharina;Wang, Jingnan;Li, Xiang
对来自动态 FDG 正电子发射断层扫描/计算机断层扫描 (PET/CT) 罐的肝细胞癌 (HCC) 以及健康肝组织区域进行了动力学建模分析。基于肝动脉和门静脉的图像衍生输入函数，对各种动力学模型进行相互比较，以检查HCC是否可以分类以及在动力学参数内是否与健康组织不同。从PET动态图像中提取时间活动曲线（TAC），对10名患者FDG PET/CT扫描的14个HCC和10个健康肝脏区域进行分析。融合的 PET/CT 图像中还描绘了肝动脉和门静脉，并将其用作输入函数。将四种动力学模型应用于 TAC，使用两种或仅一种输入函数。根据 Akaike 和 Schwartz 以及 F 检验，使用多种信息标准对结果进行分析。配对学生的 t 检验用于确定 HCC 和健康区域之间的差异。所有应用模型均显示 HCC 和健康肝脏之间 k(3) 的 p < 0.01 存在显着差异，并且四分之三的模型产生几乎相同的 k(3) = 0.03 min(-1) 和 K-i = 0.03 min(-1) 值。根据信息标准测试，对于 HCC TAC，显然首选仅具有静脉输入功能的简单两组织模型。将所有 HCC 区域分别分为 HCC 与健康比率低和高的两组后，该模型还显示出这两组之间 k(3) 的显着差异。 总之，结果表明门静脉足以描述 HCC 和健康肝脏区域的动态 FDG 过程。
A kinetic modeling analysis was performed on hepatocellular carcinoma (HCC) as well as healthy liver tissue regions from dynamic FDG positron emission tomographys/computer tomography (PET/CT) cans. On basis of image derived input function from hepatic artery and portal vein, various kinetic models were compared among each other in order to check whether HCC can be classified and differ from healthy tissue within the kinetic parameters.14 HCC and 10 healthy liver regions from FDG PET/CT scans of ten patients were analyzed from their time activity curves (TACs) were extracted from the PET dynamic images. Also the hepatic artery and the portal vein were delineated in the fused PET/CT images, which were used as input functions. Four kinetic models were applied to the TACs, using both or only one input function. Results were analyzed with several information criteria according to Akaike and Schwartz as well as be the F-Test. The paired student's t-test was used to determine the differences between HCC and healthy regions.All applied models revealed significant differences of p < 0.01 of k(3) between HCC and healthy liver and three out of four models produced almost identical values for k(3) = 0.03 min(-1) and K-i = 0.03 min(-1). According to the information criteria tests, a simple two-tissue model with only a venous input function is clearly preferred in case of HCC TACs. After dividing all HCC regions into two groups having a low and a high HCC-to-healthy ratio, respectively, this model also showed significant differences of k(3) between these two groups.In conclusion, results indicate that the portal vein is sufficient to describe kinetic FDG processes in HCC and healthy liver regions.