Clinical comparison of Tc-99m N,N'-bis(mercaptoacetamido)ethylenediamine and [131I]ortho-iodohippurate for evaluation of renal tubular function: concise communication.
Clinical comparison of Tc-99m N,N'-bis(mercaptoacetamido)ethylenediamine and [131I]ortho-iodohippurate for evaluation of renal tubular function: concise communication.
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Tc-99m N,N-双(巯基乙酰胺)乙二胺和[131I]原碘马尿酸盐评估肾小管功能的临床比较：简明交流。
作者：
W. Klingensmith;J. Gerhold;A. Fritzberg;V. Spitzer;C. Kuni;C. J. Singer;R. Weil
最近在正常动物中的实验表明，Tc-99 m N，N '-双（巯基乙酰氨基）乙二胺（Tc-99 m DADS）是一种潜在的锝-99 m标记的[131 I]邻碘马尿酸盐（I-131 Hipp）的替代物。我们在11例肾移植患者（血清肌酐范围：0.9- 5.7 mg/dl）中比较了这两种药物。记录30分钟和排尿后的数字和模拟图像。结果表明，Tc-99 m DADS的相对萃取效率指数为76% +/- 3（平均值+/- s.e.m.），Tc-99 m DADS的前沿实质通过时间为137% +/- 6，30 min时膀胱中注射Tc-99 m DADS的百分比为I-131 Hipp的25% +/- 4（所有p均小于0.05）。40%的患者表现出一定的肝胆排泄的Tc-99 m DADS。我们的结论是，Tc-99 m DADS的生物学特性是劣于那些I-131 Hipp和Tc-99 m DADS的类似物应进行评估，试图找到一个更合适的锝-99 m标记的替代I-131 Hipp。
Recent experiments in normal animals have shown that Tc-99m N,N'-bis(mercaptoacetamido)ethylenediamine (Tc-99m DADS) is a potential technetium-99m-labeled replacement for [131I]ortho-iodohippurate(I-131 Hipp). We compared the two agents in eleven patients with renal transplants (serum creatinine range: 0.9--5.7 mg/dl). Digital and analog images were recorded for 30 min and after voiding. The results indicate that the relative extraction efficiency index of Tc-99m DADS is 76% +/- 3 (mean +/- s.e.m.), that the leading-edge parenchymal transit time of Tc-99m DADS is 137% +/- 6, and that the percentage of injected Tc-99m DADS in the bladder at 30 min is 25% +/- 4 of that of I-131 Hipp (all p less than 0.05). Forty percent of patients showed some hepatobiliary excretion of Tc-99m DADS. We conclude that the biologic properties of Tc-99m DADS are inferior to those of I-131 Hipp and that analogs of Tc-99m DADS should be evaluated in an attempt to find a more suitable technetium-99m-labeled replacement for I-131 Hipp.