A β-keto ester as a novel, efficient, and versatile ligand for copper(I)-catalyzed C-N, C-O, and C-S coupling reactions
A β-keto ester as a novel, efficient, and versatile ligand for copper(I)-catalyzed C-N, C-O, and C-S coupling reactions
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DOI：
10.1021/jo070443m
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发表时间：
2007-05-11
影响因子：
3.6
通讯作者：
Bao, Weiliang
中科院分区：
文献类型：
--
作者：
Lv, Xin;Bao, Weiliang
[图]利用2-氧环己anecarboxylate乙酯作为一种新型、高效、多功能的配体，可以在温和的条件下成功地进行各种N/O/S亲核试剂与芳基卤化物的铜催化偶联反应。以优异的收率合成了n -芳酰胺、n -芳咪唑、芳醚和芳硫醚等多种产品。
[GRAPHICS]Employing ethyl 2-oxocyclohexanecarboxylate as a novel, efficient, and versatile ligand, the copper-catalyzed coupling reactions of various N/O/S nucleophilic reagents with aryl halides could be successfully carried out under mild conditions. A variety of products including N-arylamides, N-arylimidazoles, aryl ethers, and aryl thioethers were synthesized in good to excellent yields.