Effect of anteroventral third ventricle lesions on vasopressin release by organ-cultured hypothalamo-neurohypophyseal explants.
Effect of anteroventral third ventricle lesions on vasopressin release by organ-cultured hypothalamo-neurohypophyseal explants.
复制标题
前腹第三脑室病变对器官培养的下丘脑-神经垂体外植体释放加压素的影响。
DOI：
10.1159/000123519
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发表时间：
1983
影响因子：
4.1
通讯作者：
Johnson,AK
中科院分区：
文献类型：
--
作者：
Sladek,CD;Johnson,AK
下丘脑第三脑室（AV3V）周围组织发生电解损伤的大鼠对高渗NaCl的反应表现为高钠血症和慢性饮水缺陷。这些发现提示渗透接受受损。器官培养的大鼠下丘脑-神经垂体系统（HNS）在渗透刺激下释放抗利尿激素（VP）。AV3V损伤区域的腹侧部分包括在HNS外植体中。因此，这些研究开始评估从先前制备AV3V病变的大鼠获得的HNS外植体对渗透压、乙酰胆碱或血管紧张素II的反应能力，以及VP释放的增加。
Rats with electrolytic lesions of the tissue surrounding the third ventricle (AV3V) of the hypothalamus exhibit hypernatremia and chronic drinking deficits in response to hypertonic NaCl. These findings are suggestive of impaired osmoreception. The organ-cultured rat hypothalamo-neurohypophyseal system (HNS) previously has been shown to release vasopressin (VP) in response to osmotic stimuli. The ventral portion of the region damaged by AV3V lesions is included in the HNS explant. Thus, these studies were initiated to evaluate the ability of HNS explants which were obtained from rats previously prepared with AV3V lesions to respond to an increase in osmolality, acetylcholine, or angiotensin II with an increase in VP release.