Developmental information but not promoter activity controls the methylation state of histone H3 lysine 4 on two photosynthetic genes in maize
Developmental information but not promoter activity controls the methylation state of histone H3 lysine 4 on two photosynthetic genes in maize
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DOI：
10.1111/j.1365-313x.2007.03352.x
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发表时间：
2008-02-01
期刊：
影响因子：
7.2
通讯作者：
Peterhaensel, Christoph
中科院分区：
文献类型：
--
作者：
Danker, Tania;Dreesen, Bjorn;Peterhaensel, Christoph
我们研究了与玉米 C-4 光合作用相关的两个关键基因的组蛋白 H3 甲基化与环境和发育信号的关系。根和叶中组蛋白 H3 赖氨酸 4 (H3K4) 的三甲基化受到自主细胞类型特异性发育信号的控制，这些信号与光照无关，因此与转录起始无关。 H3K4 的二甲基化和单甲基化与该过程具有拮抗作用。这些修饰已经在黄化的幼苗中建立，并且当基因通过暗处理或转录药物抑制失活时保持稳定。在特定基因位置同时检测到 H3K9 的组成型二甲基化。这些数据支持组蛋白密码模型，通过该模型，细胞类型特异性信号诱导染色质结构的形成，从而通过环境线索增强基因激活。
We have investigated the establishment of histone H3 methylation with respect to environmental and developmental signals for two key genes associated with C-4 photosynthesis in maize. Tri-methylation of histone H3 lysine 4 (H3K4) in roots and leaves was shown to be controlled by autonomous cell-type-specific developmental signals that are independent of illumination and therefore independent of the initiation of transcription. Di- and mono-methylation of H3K4 act antagonistically to this process. The modifications were already established in etiolated seedlings, and remained stable when genes were inactivated by dark treatment or pharmaceutical inhibition of transcription. Constitutive di-methylation of H3K9 was concomitantly detected at specific gene positions. The data support a histone code model whereby cell-type-specific signals induce the formation of a chromatin structure that potentiates gene activation by environmental cues.