L-NITROARGININE INCREASES BLOOD-PRESSURE IN THE RAT
L-NITROARGININE INCREASES BLOOD-PRESSURE IN THE RAT
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DOI：
10.1111/j.1440-1681.1991.tb01470.x
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发表时间：
1991-06-01
影响因子：
2.9
通讯作者：
HATTORI, K
中科院分区：
文献类型：
--
作者：
KOBAYASHI, Y;IKEDA, K;HATTORI, K
1. 研究了胍基氨基精氨酸衍生物N(G)-硝基- l -精氨酸（NO2Arg）给药1周对大鼠血压及部分血管反应的影响。与食物一起给药NO2Arg后，大鼠收缩压显著升高（体重0.023%，每只大鼠每天约2.8 mg NO2Arg）。no2arg处理大鼠胸主动脉环制剂中乙酰胆碱松弛作用明显减弱。然而，三硝酸甘油诱导的舒张在NO2Arg给药后并没有减少，提示NO2Arg给药特异性地抑制了内皮依赖性舒张。血压升高可能是因为口服NO2Arg抑制体内内皮依赖性松弛，提示EDRF的释放对血压的生理控制很重要。
1. Effects of administration of N(G)-nitro-L-arginine (NO2Arg), a guanidino nitroarginine derivative, for 1 week on blood pressure and some vascular responses of rats were studied.2. A significant rise of the systolic blood pressure was observed after the administration of NO2Arg with food (0.023% in weight, about 2.8 mg of NO2Arg per rat per day). Relaxation by acetylcholine decreased markedly in ring preparations of the thoracic aorta of NO2Arg-treated rats. However, glyceryltrinitrate-induced relaxation was not reduced after NO2Arg administration, suggesting that NO2Arg administration specifically inhibited endothelium-dependent relaxation.3. An increase of blood pressure may be because oral administration of NO2Arg inhibited endothelium-dependent relaxation in vivo suggesting that the release of EDRF is important in physiological control of blood pressure.