Rates and correlates of mortality amongst heroin users: Findings from the Australian Treatment Outcome Study (ATOS), 2001-2009
Rates and correlates of mortality amongst heroin users: Findings from the Australian Treatment Outcome Study (ATOS), 2001-2009
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DOI：
10.1016/j.drugalcdep.2010.10.021
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发表时间：
2011-06-01
影响因子：
4.2
通讯作者：
Teesson, Maree
中科院分区：
文献类型：
--
作者：
Darke, Shane;Mills, Katherine L.;Teesson, Maree
该研究旨在确定2001年至2009年期间615名海洛因使用者的澳大利亚治疗结果研究（ATOS）队列中的死亡率，标准化死亡率比（SMR）和死亡率相关性。该队列共随访4820.1人年。随访期间共发生31例死亡（队列的5%）。平均死亡年龄为34.5岁，58%为男性。最常见的死亡原因是过量（68%）。粗死亡率为6.43/1000人年，无性别差异，SMR为4.56（男性= 2.95，女性= 18.57）。与死亡率相关的唯一显著双变量（风险比= 3.69）和多变量（校正风险比= 3.03）是基线前阿片类药物过量史。死亡率低于澳大拉西亚以外的地区。由海洛因使用者治疗者进行药物过量筛查是适当的，可能有助于降低总体死亡率。(C)2010爱思唯尔爱尔兰有限公司版权所有。
The study aimed to determine mortality rates, standardised mortality ratios (SMRs), and correlates of mortality amongst the Australian Treatment Outcome Study (ATOS) cohort of 615 heroin users over the period 2001-2009. The cohort was followed for a total of 4820.1 person years. A total of 31 deaths (5% of the cohort) occurred across follow-up. The mean age at death was 34.5 years, and 58% were male. The most common cause of death was overdose (68%). The crude mortality rate was 6.43 per 1000 person years, with no gender difference, and the SMR was 4.56 (males = 2.95, females = 18.57). The only significant bivariate (hazard ratio = 3.69) and multivariate (adjusted hazard ratio = 3.03) correlate of mortality was a history of opioid overdose prior to baseline. Mortality rates were lower than those seen outside Australasia. Screening for overdose by those treating heroin users would be appropriate, and may contribute to reductions in overall mortality. (C) 2010 Elsevier Ireland Ltd. All rights reserved.