NHC-catalyzed Truce-Smiles rearrangement of N-aryl methacrylamides for the synthesis of trans-cinnamides
NHC-catalyzed Truce-Smiles rearrangement of N-aryl methacrylamides for the synthesis of trans-cinnamides
复制标题
NHC 催化 N-芳基甲基丙烯酰胺的 Truce-Smiles 重排合成反式肉桂酰胺
DOI：
10.1039/d1ob00443c
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发表时间：
2021-03-31
影响因子：
3.2
通讯作者：
Zhou, Bingwei
中科院分区：
文献类型：
--
作者：
Hu, Yuanyuan;Wang, Zhen;Zhou, Bingwei
Herein we describe a NHC-catalyzed Truce-Smiles rearrangement of N-aryl methacrylamides which enables the cleavage of an inert aryl C-N bond. A range of trans-cinnamides could be obtained by the direct construction of a C-(aryl)-C-(alkenyl) bond and functional groups such as Br, Cl, CN, and pyridinyl are compatible with NHC catalysis. The reaction features high atom-economy, transition-metal free catalysis, and easily available substrates.
