Acral lentiginous melanoma in situ:: A study of nine cases
Acral lentiginous melanoma in situ:: A study of nine cases
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DOI：
10.1097/00000372-200408000-00004
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发表时间：
2004-08-01
影响因子：
1.1
通讯作者：
Cho, KH
中科院分区：
文献类型：
--
作者：
Kwon, IH;Lee, JH;Cho, KH
肢端雀斑样黑色素瘤（ALM）是亚洲人最常见的皮肤黑色素瘤类型。然而，遇到一个病人只显示组织学特征的ALM原位是不寻常的。在这里，我们描述了9例ALM原位包括抗S100蛋白和HMB-45免疫组化染色的临床和组织学特征。所有患者均有较长的临床病史。临床上，病变的特点是在甲板上的纵向色素条纹，近端或侧甲襞上的黑色色素沉着，以及不规则的边界和杂色色素沉着的唯一或拇指。所有患者均行病灶全切除。所有病变，在活检和切除标本显示更多的黑素细胞通常位于基底层的表皮。没有皮肤侵犯。术后随访6个月至12年，所有患者均无复发。这些结果表明，ALM可以在许多年内缓慢演变。
An acral lentiginous melanoma (ALM) is the most common type of cutaneous melanoma in Asians. However, it is unusual to encounter a patient showing only the histologic features of an ALM in situ. Here we describe clinical and histologic features of nine cases of ALM in situ including immunohistochemical staining with anti-S100 protein and HMB-45. All the patients had a long clinical history. Clinically, the lesions were characterized by a longitudinal pigmented streak in the nail plates, black pigmentation on the proximal or lateral nail fold, and an irregular border and variegated pigmentation on the sole or thumb. Total resections of the lesions were performed in all patients. All lesions, in both biopsy and excisional specimens demonstrated more melanocytes generally located in the basal layer of the epidermis. There was no dermal invasion. No recurrence of the disease had occurred in any patient after a follow-up period of between 6 months to 12 years after surgery. These results suggest that ALM can evolve slowly over many years.