Imaging performance of a hybrid x-ray computed tomography-fluorescence molecular tomography system using priors
Imaging performance of a hybrid x-ray computed tomography-fluorescence molecular tomography system using priors
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DOI：
10.1118/1.3368603
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发表时间：
2010-05-01
期刊：
影响因子：
3.8
通讯作者：
Ntziachristos, Vasilis
中科院分区：
文献类型：
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作者：
Ale, Angelique;Schulz, Ralf B.;Ntziachristos, Vasilis
研究方法：将结构先验信息的方法包括在反问题中，通过添加一个惩罚项的最小化函数用于图像重建。结果进行了比较，以他们的表现与模拟和实验数据从肺部炎症动物模型和对反转时实现不使用priors.Results：使用先验的重要性，在独立的反转也展示了高空间采样模拟和实验数据。还讨论了解决小动物荧光生物分布的最佳性能方法。结论：在荧光生物分布的重建中包含来自X射线CT数据的先验信息，可以提高模拟数据和实验数据的重建图像和验证图像之间的一致性。
Methods: Approaches that incorporate structural prior information were included in the inverse problem by adding a penalty term to the minimization function utilized for image reconstructions. Results were compared as to their performance with simulated and experimental data from a lung inflammation animal model and against the inversions achieved when not using priors.Results: The importance of using priors over stand-alone inversions is also showcased with high spatial sampling simulated and experimental data. The approach of optimal performance in resolving fluorescent biodistribution in small animals is also discussed.Conclusions: Inclusion of prior information from x-ray CT data in the reconstruction of the fluorescence biodistribution leads to improved agreement between the reconstruction and validation images for both simulated and experimental data.