ARE ADVANCED GLYCATION END-PRODUCTS ASSOCIATED WITH AMYLOIDOSIS IN ALZHEIMERS-DISEASE
ARE ADVANCED GLYCATION END-PRODUCTS ASSOCIATED WITH AMYLOIDOSIS IN ALZHEIMERS-DISEASE
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DOI：
10.1097/00001756-199504190-00010
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发表时间：
1995-04-19
期刊：
影响因子：
1.7
通讯作者：
HORIUCHI, S
中科院分区：
文献类型：
--
作者：
KIMURA, T;TAKAMATSU, J;HORIUCHI, S
最近的研究表明，美拉德反应的晚期糖基化终产物(AGE)与阿尔茨海默病的淀粉样变性有关。为了评估这种可能性，目前的免疫组织化学研究是使用针对AGE蛋白的单抗来定位阿尔茨海默病大脑皮层中的AGE。淀粉样血管病经典老年斑和血管壁核心中的β-淀粉样蛋白沉积未显示AGE阳性反应，而原始斑块、经典斑块冠状突起和一些神经胶质细胞呈AGE阳性反应。这些发现与年龄可能主要与阿尔茨海默病淀粉样变性有关的说法不一致。
RECENT studies have suggested that advanced glycation end-products (AGE) of the Maillard reaction are associated with amyloidosis in Alzheimer's disease. To evaluate this possibility, the present immunohistochemical study was undertaken to locate AGE in cerebral cortices of Alzheimer's disease, using a monoclonal antibody specific for AGE-proteins. Deposits of beta-amyloid protein within cores of classic senile plaques and vascular walls in amyloid angiopathy showed no AGE-positive reaction, while primitive plaques, coronas of classic plaques and some glial cells were positive for AGE. These findings are inconsistent with the suggestion that AGE may be involved primarily in amyloidosis in Alzheimer's disease.