Antimycins A10∼A16, seven new antimycin antibiotics produced by Streptomyces spp. SPA-10191 and SPA-8893
Antimycins A10∼A16, seven new antimycin antibiotics produced by Streptomyces spp. SPA-10191 and SPA-8893
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DOI：
10.1038/ja.2005.61
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发表时间：
2005-07-01
影响因子：
3.3
通讯作者：
Saji, I
中科院分区：
文献类型：
--
作者：
Hosotani, N;Kumagai, K;Saji, I
从链霉菌（Streptomycesspp.）的发酵液中分离得到7个新的抗霉素抗生素，命名为抗霉素A（10）、A（11）、A（12）、A（13）、A（14）、A（15）和A（16）。SPA-10191和SPA-8893，沿着与已知的抗霉素A（1）、A（2）、A（3）和A（4）。通过光谱分析，包括2D NMR技术，确定了新的抗霉素的结构。这些化合物对产朊假丝酵母具有抗真菌活性。
Seven new antimycin antibiotics, named antimycins A(10), A(11), A(12), A(13), A(14), A(15) and A(16), were isolated from the fermentation broth of strains of Streptomyces spp. SPA-10191 and SPA-8893, along with known antimycins A(1), A(2), A(3) and A(4). The structures of the new antimycins were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited antifungal activity against Candida utilis.