Hydroxyapatite implants with designed internal architecture
Hydroxyapatite implants with designed internal architecture
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DOI：
10.1023/a:1011203226053
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发表时间：
2001-01-01
影响因子：
3.7
通讯作者：
Feinberg, SE
中科院分区：
文献类型：
--
作者：
Chu, TMG;Halloran, JW;Feinberg, SE
多孔羟基磷灰石（HA）作为骨移植材料在临床上已经应用了几十年。传统上，这些HA中的孔要么从珊瑚外骨骼图案获得，要么从起始HA粉末中嵌入的有机颗粒获得。这两种方法对孔结构的控制非常有限。提出了一种制备具有设计孔道的多孔HA的新方法。该方法本质上是一种失模技术，使用立体光刻制成的阴模和高负载的可固化HA悬浮液作为陶瓷载体。具有设计通道和连接图案的植入物首先从计算机辅助设计（CAD）软件和计算机断层扫描（CT）数据生成。设计的负像用于在具有环氧树脂的立体光刻设备上构建模具。配制在丙氧基化新戊二醇二丙烯酸酯（PNPGDA）和丙烯酸异辛酯（IBA）中的40体积% HA悬浮液。将HA悬浮液浇铸到环氧树脂模具中并在85 ℃下固化成固体。通过热解除去模具和丙烯酸酯粘合剂，然后进行HA绿色体烧结。采用这种方法，成功地构建了具有六种不同通道设计的种植体，并在烧结的HA种植体中再现了所设计的通道。在烧结的HA植入物中产生的通道直径在366 μ m和968 μ m之间，标准偏差为50 μ m或更小。结果表明，利用本研究开发的技术可以构建具有设计连接模式和良好控制通道尺寸的HA植入物。(C)2001 Kluwer Academic Publishers.
Porous hydroxyapatite (HA) has been used as a bone graft material in the clinics for decades. Traditionally, the pores in these HAs are either obtained from the coralline exoskeletal patterns or from the embedded organic particles in the starting HA powder. Both processes offer very limited control on the pore structure. A new method for manufacturing porous HA with designed pore channels has been developed. This method is essentially a lost-mold technique with negative molds made with Stereolithography and a highly loaded curable HA suspension as the ceramic carrier. Implants with designed channels and connection patterns were first generated from a Computer-Aided-Design (CAD) software and Computer Tomography (CT) data. The negative images of the designs were used to build the molds on a stereolithography apparatus with epoxy resins. A 40 vol% HA suspension in propoxylated neopentyl glycol diacrylate (PNPGDA) and iso-bornyl acrylate (IBA) was formulated. HA suspension was cast into the epoxy molds and cured into solid at 85 degreesC. The molds and acrylate binders were removed by pyrolysis, followed by HA green body sintering. With this method, implants with six different channel designs were built successfully and the designed channels were reproduced in the sintered HA implants. The channels created in the sintered HA implants were between 366 mum and 968 mum in diameter with standard deviations of 50 mum or less. The porosity created by the channels were between 26% and 52%. The results show that HA implants with designed connection pattern and well controled channel size can be built with the technique developed in this study. (C) 2001 Kluwer Academic Publishers.