Cirrus High-Definition Optical Coherence Tomography Compared with Stratus Optical Coherence Tomography in Glaucoma Diagnosis
Cirrus High-Definition Optical Coherence Tomography Compared with Stratus Optical Coherence Tomography in Glaucoma Diagnosis
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DOI：
10.1167/iovs.08-2988
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发表时间：
2010-01-01
影响因子：
4.4
通讯作者：
Zarranz-Ventura, Javier
中科院分区：
文献类型：
--
作者：
Moreno-Montanes, Javier;Olmo, Natalia;Zarranz-Ventura, Javier
目的.比较Cirrus光学相干断层扫描（OCT）和Stratus OCT对青光眼视网膜神经纤维层（RNFL）的诊断价值。130例正常人和86例青光眼患者被纳入这项前瞻性研究。评价OCT的信号强度。比较了全球RNFL平均厚度在四个象限和每个时钟小时扇区的敏感性和特异性。绘制RNFL厚度的受试者工作特征（ROC）曲线、ROC下面积（AUC）和似然比（LR）。通过使用Bland-Altman方法和kappa（kappa）系数计算OCT之间的一致性。23%的Stratus OCT检查病例和1.9%的Cirrus OCT检查病例的信号强度低于6（P = 0.01）。在信号强度>= 6的病例中，Cirrus OCT的平均信号强度高于Stratus OCT（P = 0.01）。Cirrus测量的RNFL较Stratus OCT测量的厚（P < 0.05）。对于全球RNFL平均值，Stratus和Cirrus OCT的AUC分别为0.829和0.837（P = 0.706）。两种OCT的LR在总体RNFL分类中相似，但在象限中不同。一致性界限的宽度在42.16和97.79 μ m之间变化。平均RNFL分类几乎完全一致（kappa = 0.82）。Cirrus OCT的扫描质量优于Stratus OCT，尤其是在昏迷眼。在扫描质量良好的病例中，灵敏度和特异性以及AUC相似。最好的协议是在全球平均RNFL分类。协议的限制宽度超过OCT的分辨率限制。（Invest Ophthalmol维斯科学。2010; 51：335-343）DOI：10.1167/iovs.08-2988
PURPOSE. To compare the retinal nerve fiber layer (RNFL) evaluation using Cirrus optical coherence tomography (OCT) and Stratus OCT in glaucoma diagnosis.METHODS. One hundred thirty normal and 86 patients with glaucoma were included in this prospective study. The signal strengths of the OCTs were evaluated. The sensitivities and specificities of global RNFL average thickness were compared in the four quadrants and in each clock hour sector. Receiver operating characteristic (ROC) curves, areas under the ROC (AUC), and the likelihood ratio (LR) were plotted for RNFL thickness. Agreement between the OCTs was calculated by using the Bland-Altman method and kappa (kappa) coefficient.RESULTS. Twenty-three percent of all cases examined with Stratus OCT and 1.9% examined with Cirrus OCT had a signal strength below 6 (P = 0.01). In cases with signal strengths >= 6, the mean signal strength was higher with Cirrus OCT than with Stratus OCT (P = 0.01). The RNFL measurements by Cirrus were thicker than those of Stratus OCT (P < 0.05). The AUCs were 0.829 for Stratus and 0.837 for Cirrus OCT (P = 0.706) for global RNFL average. LRs were similar in both OCTs in global RNFL classification but varied in quadrants. The widths of the limits of agreement varied between 42.16 and 97.79 mu m. There was almost perfect agreement (kappa = 0.82) in the average RNFL classification.CONCLUSIONS. Cirrus OCT has better scan quality than Stratus OCT, especially in glaucomatous eyes. In cases with good-quality scans, the sensitivity and specificity, and AUCs were similar. The best agreement was in the global average RNFL classification. The widths of limits of agreements exceed the limits of resolution of the OCTs. (Invest Ophthalmol Vis Sci. 2010; 51:335-343) DOI:10.1167/iovs.08-2988