Inbred mouse strains differ in the regulation of startle and prepulse inhibition of the startle response
Inbred mouse strains differ in the regulation of startle and prepulse inhibition of the startle response
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DOI：
10.1037/0735-7044.111.6.1353
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发表时间：
1997-12-01
影响因子：
1.9
通讯作者：
Collins, AC
中科院分区：
文献类型：
--
作者：
Bullock, AE;Slobe, BS;Collins, AC
在动物中已经观察到惊吓反应和惊吓反应的适应性（前脉冲抑制和习惯化）。本文报道的研究筛选了8个近交系小鼠品系，以确定遗传因素是否影响这些行为。应变差异被发现在这两个敏感性的听觉和触觉惊吓的幅度，以及幅度的前脉冲抑制（PPI）的触觉和声惊吓。两种惊吓反应和两种形式的PPI都没有显著相关性，这表明不同的基因调节这两种形式的惊吓和PPI。声-声PPI显着相关，然而，海马听觉门控（TC比）表明重叠的基因，调节这2种形式的感觉门控。
The startle response and adaptability of the startle response (prepulse inhibition and habituation) have been observed in animals. The studies reported here screened 8 inbred mouse strains to determine whether genetic factors influence these behaviors. Strain differences were found in both the sensitivity to acoustic startle and the magnitude of both the auditory and tactile startle as well as the magnitude of prepulse inhibition (PPI) of both tactile and acoustic startle. Neither the 2 startle responses nor the 2 forms of PPI were significantly correlated with one another, suggesting that different genes regulate these 2 forms of startle and PPI. Acoustic-acoustic PPI was significantly correlated, however, with hippocampal auditory gating (TC ratio) suggesting an overlap in the genes that regulate these 2 forms of sensory gating.