Multiple modes of photodynamic action by cercosporin.
Multiple modes of photodynamic action by cercosporin.
复制标题
尾孢菌素的多种光动力作用模式。
DOI：
10.1111/j.1751-1097.1988.tb02767.x
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发表时间：
1988
影响因子：
3.3
通讯作者：
Daub,ME
中科院分区：
文献类型：
--
作者：
Hartman,PE;Dixon,WJ;Dahl,TA;Daub,ME
尾孢菌素（Cercosporin）是由植物病原真菌合成的4，9-二羟基苝-3，10-醌类化合物之一，在溶液中光照时大量产生单线态氧。在还原剂麦角硫因（2-巯基-L-组氨酸甜菜碱）或尿酸盐的存在下，单线态氧的产生显著降低，超氧化物的产生大大增强。麦角硫因和尿酸盐均以等摩尔量的蛋氨酸（传统上用于此类测定的试剂）引起的约25倍的速率增强超氧化物产生。在不同环境条件下产生不同活性氧物质的这种“转换”在生物过程中可能是重要的，在这种情况下，植物病原体杀死宿主细胞。
Cercosporin, one of a number of 4,9‐dihydroxyperylene‐3,10‐quinones synthesized by plant pathogenic fungi, abundantly produces singlet oxygen when illuminated in solution. Singlet oxygen production is substantially decreased and superoxide production is greatly enhanced in the presence of the reducing agents ergothioneine (2‐thiol‐L‐histidine betaine) or urate. Both ergothioneine and urate enhance superoxide production at a rate approximately 25‐fold that elicited by an equimolar amount of methionine, the agent that is traditionally used in such assays. Such ‘switching’ in production of different active oxygen species under different environmental conditions may be of significance in biological processes, in this case host cell killing by the plant pathogen.