Granulocyte colony stimulating factor exacerbates antineutrophil cytoplasmic antibody vasculitis
Granulocyte colony stimulating factor exacerbates antineutrophil cytoplasmic antibody vasculitis
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DOI：
10.1136/annrheumdis-2012-202160
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发表时间：
2013-06-01
影响因子：
27.4
通讯作者：
Robson, Michael G.
中科院分区：
文献类型：
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作者：
Freeley, Simon J.;Coughlan, Alice M.;Robson, Michael G.
目的粒细胞集落刺激因子（GCSF）在动员骨髓中性粒细胞方面具有重要作用，但也具有一系列促炎作用。因此，我们决定调查的作用，GCSF在抗中性粒细胞胞浆抗体（ANCA）vasculitis.Methods我们测定了38例活动性ANCA血管炎与31个年龄匹配的对照组相比，血清中的GCSF水平，并评估了人中性粒细胞对ANCA的反应的GCSF启动的效果。结果活动性ANCA血管炎患者血清GCSF水平显著高于年龄匹配的健康对照组（平均38.04vs18.35pg/ml，P < 0.01），而活动性ANCA血管炎患者血清GCSF水平显著高于年龄匹配的健康对照组（平均38.04vs18.35pg/ml，P < 0.01）。
Objectives Granulocyte colony stimulating factor (GCSF) is important in mobilising neutrophils from the bone marrow but also has a range of proinflammatory effects. We therefore decided to investigate the role of GCSF in antineutrophil cytoplasmic antibody (ANCA) vasculitis.Methods We measured GCSF levels in the serum of 38 patients with active ANCA vasculitis compared with 31 age-matched controls, and assessed the effect of GCSF priming on the response of human neutrophils to ANCA. We also examined the effect of exogenous GCSF administration in a murine model of antimyeloperoxidase (anti-MPO) vasculitis, and the effect of GCSF on murine neutrophil activation.Results The serum levels of GCSF in patients with active ANCA vasculitis were significantly higher than those of age matched healthy controls (mean 38.04 vs 18.35 pg/ml, p