Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival
Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival
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DOI：
10.1002/ijc.23527
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发表时间：
2008-08-15
影响因子：
6.4
通讯作者：
Svanvik, Joar
中科院分区：
文献类型：
--
作者：
Shabo, Ivan;Stal, Olle;Svanvik, Joar
单核/巨噬细胞谱系的细胞在肿瘤细胞迁移、侵袭和转移中起重要作用。体外和体内动物模型中巨噬细胞与癌细胞的融合导致转移潜力增加的杂交。对原发性乳腺癌细胞进行巨噬细胞抗原表征，以检测巨噬细胞的表型相似性是否与早期远处复发有关。研究人员对127名乳腺癌患者进行了CD163、MAC387和CD68的免疫染色，随访时间中位数为13年。肿瘤相关巨噬细胞表达所有3种抗原。CD163 - 48%, MAC387 - 14%， CD68不表达。tgf - β染色强度与CD163和MAC387表达呈正相关。比较CD163在癌细胞中的表达与DNA倍体、诺丁汉组织学分级、tnm分期、淋巴结状态、雌激素受体的存在、远处转移的发生和生存率。组织学级别越高的癌症表达CD163的程度越高。表达MAC387的细胞在CD163阳性细胞比例较高的癌症中更为常见。多因素分析显示，巨噬细胞抗原CD163在乳腺癌细胞中的表达对远处转移的发生和患者生存时间的缩短具有预后影响。(c) 2008 Wiley-Liss, Inc。
Cells of the monocyte/macrophage lineage are important for tumour cell migration, invasion and metastasis. Fusion between macrophages and cancer cells in animal models in vitro and in vivo causes hybrids with increased metastatic potential. Primary breast cancer cells were characterized for macrophage antigens to test if phenotypic resemblance to macrophages is related to early distant recurrence. Immunostaining for CD163, MAC387 and CD68 was performed in a breast cancer tissue micro array from 127 patients consequently followed up for a median of 13 years. Tumour-associated macrophages expressed all 3 antigens. The breast cancers expressed CD163 to 48%, MAC387 to 14% while CD68 was not expressed. TGF-beta staining intensity was positively related to both CD163 and MAC387 expression. Expression of CD163 in the cancer cells was compared to their DNA ploidy, Nottingham Histological Grade, TNM-stage, node state, presence of estrogen receptors and occurrence of distant metastases and survival. Cancers of a more advanced histological grade expressed CD163 to a higher extent. Cells expressing MAC387 were more common in cancers with a high proportion of CD163 positive cells. Multivariate analysis showed that expression of the macrophage antigen CD163 in breast cancer cells has a prognostic impact on the occurrence of distant metastases and reduced patient survival time. (c) 2008 Wiley-Liss, Inc.