Time domain, geometrical and frequency domain analysis of cardiac vagal outflow:: effects of various respiratory patterns
Time domain, geometrical and frequency domain analysis of cardiac vagal outflow:: effects of various respiratory patterns
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DOI：
10.1046/j.1365-2281.2001.00337.x
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发表时间：
2001-05-01
期刊：
影响因子：
--
通讯作者：
Scheinin, H
中科院分区：
文献类型：
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作者：
Penttilä, J;Helminen, A;Scheinin, H
本研究的目的是比较四种不同心率变异性 (HRV) 测量方法在评估心脏迷走神经流出量方面的适用性，特别是呼吸模式的影响。研究了8名志愿者静脉输注格隆溴铵（5μg·kg(-1)·h(-1)，持续2h）在自主呼吸和受控呼吸（15min（-1））期间的抗胆碱能作用，以及不同固定呼吸频率（6-15-24min（-1））和过度通气对12名受试者的影响。通过心电图记录评估心脏迷走神经活动，其中计算以下 HRV 测量值：高频 (HF) 频谱分量、根据庞加莱图分析的瞬时 RR 间期 (RRI) 变异性 (SD1)、连续 RRI 之间大于 50 ms 的差异百分比 (pNN50) 以及连续 RRI 均方差的平方根 (RMSSD)。平均而言，格隆溴铵将 HF 光谱成分降低 99.8%，SD1 降低 91.3%，pNN50 降低 100%，RMSSD 降低 97.0%。呼吸模式从受控到自发的改变显着降低了 HF 成分和 pNN50，但不影响 SD1 或 RMSSD。快速呼吸频率（24 min(-1)）减少了心力衰竭成分，但对其他措施没有影响。通过频谱分析技术可靠地评估心脏迷走神经流出量需要控制呼吸频率。庞加莱图短期 RRI 变异性的定量几何分析和时域测量 RMSSD 并未受到呼吸频率变化的显着影响，表明这些指数更适合测量“自由奔跑”动态条件下的心脏迷走神经流出量。
The purpose of this study was to compare the applicability of four different measures of heart rate variability (HRV) in the assessment of cardiac vagal outflow, with special reference to the effect of breathing pattern. The anticholinergic effects of an intravenous glycopyrrolate infusion (5 mug kg(-1) h(-1) for 2 h) during spontaneous and controlled (15 min(-1)) breathing rate were investigated in eight volunteers, and the effects of different fixed breathing rates (6-15-24 min(-1)) and hyperventilation in 12 subjects. Cardiac vagal activity was assessed by ECG recordings in which the following measures of HRV were computed: the high-frequency (HF) spectral component, the instantaneous RR interval (RRI) variability (SD1) analysed from the Poincare plots, the percentage of differences between successive RRIs greater than 50 ms (pNN50), and the square root of the mean squared differences of successive RRIs (RMSSD). On average, glycopyrrolate reduced the HF spectral component by 99.8%, SD1 by 91.3%, pNN50 by 100% and RMSSD by 97.0%. The change of breathing pattern from controlled to spontaneous decreased significantly the HF component and pNN50, but did not affect SD1 or RMSSD. Rapid breathing rate (24 min(-1)) decreased the HF component, but had no effects on the other measures. A controlled breathing rate is needed for a reliable assessment of cardiac vagal outflow by the spectral analysis technique. The quantitative geometrical analysis of short-term RRI variability from the Poincare plots and the time domain measure RMSSD were not significantly affected by changes in the breathing rate, suggesting that these indices are more suitable for the measurement of cardiac vagal outflow during the 'free-running' ambulatory conditions.